Human Gene WDR45 (ENST00000356463.7) from GENCODE V44
Description: Homo sapiens WD repeat domain 45 (WDR45), transcript variant 1, mRNA. (from RefSeq NM_007075) RefSeq Summary (NM_007075): This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000356463.7 Gencode Gene: ENSG00000196998.19 Transcript (Including UTRs) Position: hg38 chrX:49,074,640-49,101,121 Size: 26,482 Total Exon Count: 12 Strand: - Coding Region Position: hg38 chrX:49,074,803-49,078,095 Size: 3,293 Coding Exon Count: 10
ID:WIPI4_HUMAN DESCRIPTION: RecName: Full=WD repeat domain phosphoinositide-interacting protein 4; Short=WIPI-4; AltName: Full=WD repeat-containing protein 45; TISSUE SPECIFICITY: Ubiquitously expressed, with high expression in skeletal muscle and heart. Weakly expressed in liver and placenta. Expression is down-regulated in pancreatic and in kidney tumors. SIMILARITY: Belongs to the WD repeat SVP1 family. SIMILARITY: Contains 3 WD repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y484
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
