Human Gene CSTF2 (ENST00000372972.7) from GENCODE V44
Description: Homo sapiens cleavage stimulation factor subunit 2 (CSTF2), transcript variant 2, mRNA. (from RefSeq NM_001325) RefSeq Summary (NM_001325): This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000372972.7 Gencode Gene: ENSG00000101811.15 Transcript (Including UTRs) Position: hg38 chrX:100,820,391-100,841,520 Size: 21,130 Total Exon Count: 14 Strand: + Coding Region Position: hg38 chrX:100,820,417-100,838,361 Size: 17,945 Coding Exon Count: 13
ID:CSTF2_HUMAN DESCRIPTION: RecName: Full=Cleavage stimulation factor subunit 2; AltName: Full=CF-1 64 kDa subunit; AltName: Full=Cleavage stimulation factor 64 kDa subunit; Short=CSTF 64 kDa subunit; Short=CstF-64; FUNCTION: One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity). SUBUNIT: The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). CSTF2 directly interacts with CSTF3, SYMPK and RPO2TC1. Interacts with HSF1 in heat-stressed cells. Interacts with CPSF2, CPSF3 and FIP1L1. Interacts with DDX1. INTERACTION: Q99728:BARD1; NbExp=5; IntAct=EBI-711360, EBI-473181; P53999:SUB1; NbExp=3; IntAct=EBI-711374, EBI-998260; SUBCELLULAR LOCATION: Nucleus. Note=Localized with DDX1 in cleavage bodies. INDUCTION: Up-regulated during the G0 to S phase transition. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Contains 1 RRM (RNA recognition motif) domain. SEQUENCE CAUTION: Sequence=CAI42681.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P33240
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BioCarta from NCI Cancer Genome Anatomy Project h_cpsfPathway - Polyadenylation of mRNA
Reactome (by CSHL, EBI, and GO)
Protein P33240 (Reactome details) participates in the following event(s):
R-HSA-5696813 TSEN complex cleaves the intron from pre-tRNA R-HSA-72231 Cleavage and Polyadenylation R-HSA-77590 Recruitment of CstF to the CPSF Bound Pre-mRNA R-HSA-72180 Cleavage of mRNA at the 3'-end R-HSA-77592 Cleavage of Intronless Pre-mRNA at 3'-end R-HSA-77593 Cleavage and polyadenylation of Intronless Pre-mRNA R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-77591 Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-8849157 TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally R-HSA-156661 Formation of Exon Junction Complex R-HSA-6784531 tRNA processing in the nucleus R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-77595 Processing of Intronless Pre-mRNAs R-HSA-72187 mRNA 3'-end processing R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-72306 tRNA processing R-HSA-72172 mRNA Splicing R-HSA-75067 Processing of Capped Intronless Pre-mRNA R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-73856 RNA Polymerase II Transcription Termination R-HSA-8953854 Metabolism of RNA R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)
US Server
