Human Gene ZDHHC9 (ENST00000357166.11) from GENCODE V44
Description: Homo sapiens zinc finger DHHC-type palmitoyltransferase 9 (ZDHHC9), transcript variant 1, mRNA. (from RefSeq NM_016032) RefSeq Summary (NM_016032): This gene encodes an integral membrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein forms a complex with golgin subfamily A member 7 and functions as a palmitoyltransferase. This protein specifically palmitoylates HRAS and NRAS. Mutations in this gene are associated with X-linked cognitive disability. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, May 2010]. Gencode Transcript: ENST00000357166.11 Gencode Gene: ENSG00000188706.13 Transcript (Including UTRs) Position: hg38 chrX:129,803,288-129,843,886 Size: 40,599 Total Exon Count: 11 Strand: - Coding Region Position: hg38 chrX:129,806,370-129,841,945 Size: 35,576 Coding Exon Count: 9
ID:ZDHC9_HUMAN DESCRIPTION: RecName: Full=Palmitoyltransferase ZDHHC9; EC=2.3.1.-; AltName: Full=Zinc finger DHHC domain-containing protein 9; Short=DHHC-9; Short=DHHC9; AltName: Full=Zinc finger protein 379; AltName: Full=Zinc finger protein 380; FUNCTION: The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS. CATALYTIC ACTIVITY: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA. SUBUNIT: Interacts with GOLGA7. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Highly expressed in kidney, skeletal muscle, brain, lung and liver. Absent in thymus, spleen and leukocytes. DOMAIN: The DHHC domain is required for palmitoyltransferase activity. DISEASE: Defects in ZDHHC9 are the cause of mental retardation syndromic X-linked ZDHHC9-related (MRXSZ) [MIM:300799]. A disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Some patients have marfanoid habitus as an additional feature. SIMILARITY: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily. SIMILARITY: Contains 1 DHHC-type zinc finger. SEQUENCE CAUTION: Sequence=AAD34084.1; Type=Erroneous initiation; Sequence=BAA91683.1; Type=Erroneous initiation; Sequence=BAD93044.1; Type=Erroneous initiation; Sequence=CAB82308.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y397
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
