Human Gene IL3RA (ENST00000331035.10) from GENCODE V44
Description: Homo sapiens interleukin 3 receptor subunit alpha (IL3RA), transcript variant 1, mRNA. (from RefSeq NM_002183) RefSeq Summary (NM_002183): The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012]. Gencode Transcript: ENST00000331035.10 Gencode Gene: ENSG00000185291.12 Transcript (Including UTRs) Position: hg38 chrX:1,336,785-1,382,689 Size: 45,905 Total Exon Count: 12 Strand: + Coding Region Position: hg38 chrX:1,341,766-1,382,465 Size: 40,700 Coding Exon Count: 11
ID:IL3RA_HUMAN DESCRIPTION: RecName: Full=Interleukin-3 receptor subunit alpha; Short=IL-3 receptor subunit alpha; Short=IL-3R subunit alpha; Short=IL-3R-alpha; Short=IL-3RA; AltName: CD_antigen=CD123; Flags: Precursor; FUNCTION: This is a receptor for interleukin-3. SUBUNIT: Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. DOMAIN: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding. DOMAIN: The box 1 motif is required for JAK interaction and/or activation. MISCELLANEOUS: The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. SIMILARITY: Belongs to the type I cytokine receptor family. Type 5 subfamily. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/IL3RAID40959chXp22Yp13.html"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il3ra/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P26951
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BioCarta from NCI Cancer Genome Anatomy Project h_badPathway - Regulation of BAD phosphorylation h_il3Pathway - IL 3 signaling pathway
Reactome (by CSHL, EBI, and GO)
Protein P26951 (Reactome details) participates in the following event(s):
R-HSA-450074 Interleukin-3 receptor alpha subunit binds Interleukin-3 R-HSA-450031 Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 R-HSA-879907 Tyrosine kinases phosphorylate the receptor R-HSA-879910 JAK2 is phosphorylated, activated R-HSA-913451 IL3RB is phosphorylated on Ser-585 R-HSA-879930 STAT5 is recruited by JAK2 R-HSA-921155 p-STAT5 dissociates from the receptor complex R-HSA-879934 Recruitment of SHC1 is mediated by Y593 of the common beta chain R-HSA-909738 SHP1 and SHP2 bind the common beta chain R-HSA-912757 p-S585-IL3RB binds 14-3-3 proteins R-HSA-879909 Activation of STAT5a/b by JAK2 R-HSA-879925 SHC1 bound to the common beta chain becomes tyrosine phosphorylated R-HSA-914036 SHP1 and SHP2 dephosphorylate Y628 of IL3RB R-HSA-914182 14-3-3 zeta binding allows recruitment of PI3K R-HSA-453111 Phosphorylated SHC recruits GRB2:SOS1 R-HSA-913374 Phosphorylated SHC1 recruits SHIP R-HSA-913424 The SHC1:SHIP1 complex is stabilized by GRB2 R-HSA-508247 Gab2 binds the p85 subunit of Class 1A PI3 kinases R-HSA-5672965 RAS GEFs promote RAS nucleotide exchange R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling R-HSA-449147 Signaling by Interleukins R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-168256 Immune System R-HSA-912526 Interleukin receptor SHC signaling R-HSA-451927 Interleukin-2 family signaling R-HSA-5673001 RAF/MAP kinase cascade R-HSA-5684996 MAPK1/MAPK3 signaling R-HSA-5683057 MAPK family signaling cascades R-HSA-162582 Signal Transduction
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