Human Gene NRAS (ENST00000369535.5) from GENCODE V44
  Description: Homo sapiens NRAS proto-oncogene, GTPase (NRAS), mRNA. (from RefSeq NM_002524)
RefSeq Summary (NM_002524): This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011].
Gencode Transcript: ENST00000369535.5
Gencode Gene: ENSG00000213281.5
Transcript (Including UTRs)
   Position: hg38 chr1:114,704,469-114,716,771 Size: 12,303 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg38 chr1:114,708,535-114,716,160 Size: 7,626 Coding Exon Count: 4 

Page IndexSequence and LinksPrimersMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesGeneReviewsMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:114,704,469-114,716,771)mRNA (may differ from genome)Protein (189 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  MalaCards Disease Associations
  MalaCards Gene Search: NRAS
Diseases sorted by gene-association score: noonan syndrome 6* (1229), melanocytic nevus syndrome, congenital, somatic* (1150), ras-associated autoimmune leukoproliferative disorder* (943), epidermal nevus, somatic* (849), neurocutaneous melanosis, somatic* (800), schimmelpenning-feuerstein-mims syndrome, somatic mosaic* (725), nras-related noonan syndrome* (500), thyroid cancer, nonmedullary, 2* (403), juvenile myelomonocytic leukemia* (289), noonan syndrome 1* (285), ptpn11-related noonan syndrome* (283), melanoma* (258), differentiated thyroid carcinoma* (175), colorectal cancer* (137), malignant melanoma, somatic* (58), thyroid cancer (27), acral lentiginous melanoma (25), leukemia, acute myeloid* (20), arachnoid cysts (19), mucosal melanoma (18), neuroblastoma (15), meningeal melanomatosis (15), erdheim-chester disease (13), autoimmune lymphoproliferative syndrome (13), skin melanoma (12), uveal melanoma (12), leukemia (11), myelodysplastic syndrome (11), malignant conjunctival melanoma (11), syringomyelia (11), malignant skin fibrous histiocytoma (11), malignant dermis tumor (11), conventional fibrosarcoma (10), myelodysplastic myeloproliferative cancer (10), ocular melanoma (9), central nervous system melanocytic neoplasm (9), conjunctival cancer (9), benign struma ovarii (8), marcus gunn phenomenon (8), melanomatosis (8), ovarian melanoma (8), cellular congenital mesoblastic nephroma (7), core binding factor acute myeloid leukemia (7), integumentary system cancer (7), malignant spindle cell melanoma (7), congenital mesoblastic nephroma (7), lymphoproliferative syndrome (7), vulvar melanoma (6), small cell sarcoma (6), malignant struma ovarii (6), liver angiosarcoma (6), retinitis pigmentosa 30 (5), gamma heavy chain disease (5), meningeal melanocytoma (5), acneiform dermatitis (5), leukodystrophy, hypomyelinating, 2 (4), leukemia, chronic myeloid, somatic (2), cell type cancer (1), aplastic anemia (1), leukemia, acute promyelocytic, somatic (1), autonomic nervous system neoplasm (1), peripheral nervous system neoplasm (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 33.54 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 365.22 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -46.30131-0.353 Picture PostScript Text
3' UTR -903.673625-0.249 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005225 - Small_GTP-bd_dom
IPR001806 - Small_GTPase
IPR020849 - Small_GTPase_Ras

Pfam Domains:
PF00071 - Ras family

ModBase Predicted Comparative 3D Structure on Q5U091
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein SequenceProtein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005525 GTP binding

Biological Process:
GO:0007165 signal transduction

Cellular Component:
GO:0016020 membrane

-  Descriptions from all associated GenBank mRNAs
  LF206270 - JP 2014500723-A/13773: Polycomb-Associated Non-Coding RNAs.
MA441847 - JP 2018138019-A/13773: Polycomb-Associated Non-Coding RNAs.
LF213712 - JP 2014500723-A/21215: Polycomb-Associated Non-Coding RNAs.
MA449289 - JP 2018138019-A/21215: Polycomb-Associated Non-Coding RNAs.
BC013214 - Homo sapiens, clone IMAGE:3446533, mRNA.
AY941100 - Homo sapiens NRAS mRNA, 3' UTR, partial sequence.
LF352827 - JP 2014500723-A/160330: Polycomb-Associated Non-Coding RNAs.
MA588404 - JP 2018138019-A/160330: Polycomb-Associated Non-Coding RNAs.
LF352826 - JP 2014500723-A/160329: Polycomb-Associated Non-Coding RNAs.
MA588403 - JP 2018138019-A/160329: Polycomb-Associated Non-Coding RNAs.
CS544935 - Sequence 44 from Patent WO2006028967.
DL262769 - Regulation of Oncogenes by MicroRNAs.
HW270248 - JP 2012105669-A/44: Regulation of Oncogenes by MicroRNAs.
JA072114 - Sequence 44 from Patent EP2298897.
JC192439 - Sequence 44 from Patent EP2338993.
JC246359 - Sequence 44 from Patent EP2338994.
JD204572 - Sequence 185596 from Patent EP1572962.
LF352825 - JP 2014500723-A/160328: Polycomb-Associated Non-Coding RNAs.
MA588402 - JP 2018138019-A/160328: Polycomb-Associated Non-Coding RNAs.
CS544934 - Sequence 43 from Patent WO2006028967.
DL262768 - Regulation of Oncogenes by MicroRNAs.
HW270247 - JP 2012105669-A/43: Regulation of Oncogenes by MicroRNAs.
JA072113 - Sequence 43 from Patent EP2298897.
JC192438 - Sequence 43 from Patent EP2338993.
JC246358 - Sequence 43 from Patent EP2338994.
AY941101 - Homo sapiens NRAS mRNA, 3' UTR, partial sequence.
CS544933 - Sequence 42 from Patent WO2006028967.
DL262767 - Regulation of Oncogenes by MicroRNAs.
HW270246 - JP 2012105669-A/42: Regulation of Oncogenes by MicroRNAs.
JA072112 - Sequence 42 from Patent EP2298897.
JC192437 - Sequence 42 from Patent EP2338993.
JC246357 - Sequence 42 from Patent EP2338994.
LF352824 - JP 2014500723-A/160327: Polycomb-Associated Non-Coding RNAs.
MA588401 - JP 2018138019-A/160327: Polycomb-Associated Non-Coding RNAs.
CS544932 - Sequence 41 from Patent WO2006028967.
DL262766 - Regulation of Oncogenes by MicroRNAs.
HW270245 - JP 2012105669-A/41: Regulation of Oncogenes by MicroRNAs.
JA072111 - Sequence 41 from Patent EP2298897.
JC192436 - Sequence 41 from Patent EP2338993.
JC246356 - Sequence 41 from Patent EP2338994.
LF352823 - JP 2014500723-A/160326: Polycomb-Associated Non-Coding RNAs.
MA588400 - JP 2018138019-A/160326: Polycomb-Associated Non-Coding RNAs.
BC005219 - Homo sapiens neuroblastoma RAS viral (v-ras) oncogene homolog, mRNA (cDNA clone MGC:12238 IMAGE:3826638), complete cds.
X02751 - Human N-ras mRNA and flanking regions.
CS544931 - Sequence 40 from Patent WO2006028967.
DL262765 - Regulation of Oncogenes by MicroRNAs.
HW270244 - JP 2012105669-A/40: Regulation of Oncogenes by MicroRNAs.
JA072110 - Sequence 40 from Patent EP2298897.
JC192435 - Sequence 40 from Patent EP2338993.
JC246355 - Sequence 40 from Patent EP2338994.
JD064842 - Sequence 45866 from Patent EP1572962.
JD284253 - Sequence 265277 from Patent EP1572962.
JD172472 - Sequence 153496 from Patent EP1572962.
JD244752 - Sequence 225776 from Patent EP1572962.
JD426810 - Sequence 407834 from Patent EP1572962.
JD322351 - Sequence 303375 from Patent EP1572962.
JD327151 - Sequence 308175 from Patent EP1572962.
CS544928 - Sequence 37 from Patent WO2006028967.
DL262762 - Regulation of Oncogenes by MicroRNAs.
HW270241 - JP 2012105669-A/37: Regulation of Oncogenes by MicroRNAs.
JA072107 - Sequence 37 from Patent EP2298897.
JC192432 - Sequence 37 from Patent EP2338993.
JC246352 - Sequence 37 from Patent EP2338994.
CS544927 - Sequence 36 from Patent WO2006028967.
DL262761 - Regulation of Oncogenes by MicroRNAs.
HW270240 - JP 2012105669-A/36: Regulation of Oncogenes by MicroRNAs.
JA072106 - Sequence 36 from Patent EP2298897.
JC192431 - Sequence 36 from Patent EP2338993.
JC246351 - Sequence 36 from Patent EP2338994.
JD358118 - Sequence 339142 from Patent EP1572962.
JD158094 - Sequence 139118 from Patent EP1572962.
KJ904521 - Synthetic construct Homo sapiens clone ccsbBroadEn_13915 NRAS-like gene, encodes complete protein.
AF493919 - Homo sapiens Ras family small GTP binding protein N-Ras (NRAS) mRNA, complete cds.
BT019734 - Homo sapiens neuroblastoma RAS viral (v-ras) oncogene homolog mRNA, complete cds.
BT019735 - Homo sapiens neuroblastoma RAS viral (v-ras) oncogene homolog mRNA, complete cds.
AB529065 - Synthetic construct DNA, clone: pF1KB3964, Homo sapiens NRAS gene for neuroblastoma RAS viral (v-ras) oncogene homolog, without stop codon, in Flexi system.
LF352822 - JP 2014500723-A/160325: Polycomb-Associated Non-Coding RNAs.
MA588399 - JP 2018138019-A/160325: Polycomb-Associated Non-Coding RNAs.
LF352820 - JP 2014500723-A/160323: Polycomb-Associated Non-Coding RNAs.
MA588397 - JP 2018138019-A/160323: Polycomb-Associated Non-Coding RNAs.
JD086657 - Sequence 67681 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04010 - MAPK signaling pathway
hsa04012 - ErbB signaling pathway
hsa04062 - Chemokine signaling pathway
hsa04360 - Axon guidance
hsa04370 - VEGF signaling pathway
hsa04530 - Tight junction
hsa04540 - Gap junction
hsa04650 - Natural killer cell mediated cytotoxicity
hsa04660 - T cell receptor signaling pathway
hsa04662 - B cell receptor signaling pathway
hsa04664 - Fc epsilon RI signaling pathway
hsa04720 - Long-term potentiation
hsa04722 - Neurotrophin signaling pathway
hsa04730 - Long-term depression
hsa04810 - Regulation of actin cytoskeleton
hsa04910 - Insulin signaling pathway
hsa04912 - GnRH signaling pathway
hsa04916 - Melanogenesis
hsa05200 - Pathways in cancer
hsa05211 - Renal cell carcinoma
hsa05213 - Endometrial cancer
hsa05214 - Glioma
hsa05215 - Prostate cancer
hsa05216 - Thyroid cancer
hsa05218 - Melanoma
hsa05219 - Bladder cancer
hsa05220 - Chronic myeloid leukemia
hsa05221 - Acute myeloid leukemia
hsa05223 - Non-small cell lung cancer

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000369535.1, ENST00000369535.2, ENST00000369535.3, ENST00000369535.4, hCG_38454, NM_002524, Q5U091, Q5U091_HUMAN, RP5-1000E10.2-001, uc009wgu.1, uc009wgu.2, uc009wgu.3, uc009wgu.4, uc009wgu.5
UCSC ID: ENST00000369535.5
RefSeq Accession: NM_002524
Protein: Q5U091 CCDS: CCDS877.1

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene NRAS:
noonan (Noonan Syndrome)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.