Human Gene FMO1 (ENST00000617670.6) from GENCODE V44
Description: Homo sapiens flavin containing dimethylaniline monoxygenase 1 (FMO1), transcript variant 3, mRNA. (from RefSeq NM_001282693) RefSeq Summary (NM_001282693): Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]. Gencode Transcript: ENST00000617670.6 Gencode Gene: ENSG00000010932.17 Transcript (Including UTRs) Position: hg38 chr1:171,248,494-171,285,961 Size: 37,468 Total Exon Count: 9 Strand: + Coding Region Position: hg38 chr1:171,258,088-171,285,544 Size: 27,457 Coding Exon Count: 8
ID:FMO1_HUMAN DESCRIPTION: RecName: Full=Dimethylaniline monooxygenase [N-oxide-forming] 1; EC=1.14.13.8; AltName: Full=Dimethylaniline oxidase 1; AltName: Full=Fetal hepatic flavin-containing monooxygenase 1; Short=FMO 1; FUNCTION: This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines. CATALYTIC ACTIVITY: N,N-dimethylaniline + NADPH + O(2) = N,N- dimethylaniline N-oxide + NADP(+) + H(2)O. COFACTOR: FAD. SUBCELLULAR LOCATION: Microsome membrane. Endoplasmic reticulum membrane. TISSUE SPECIFICITY: Expressed mainly in fetal liver, adult kidney and, to a lesser extent, the intestine. SIMILARITY: Belongs to the FMO family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/fmo1/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q01740
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.