Human Gene CNOT6 (ENST00000393356.7) from GENCODE V44
Description: Poly(A) nuclease involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. Has 3'-5' RNase activity. The CCR4-NOT complex functions as general transcription regulation complex (By similarity). In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. (from UniProt Q9ULM6) RefSeq Summary (NM_001370472): This gene encodes the catalytic component of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substrates. The CCR4-NOT complex plays a role in many cellular processes, including miRNA-mediated repression, mRNA degradation, and transcriptional regulation. [provided by RefSeq, Dec 2014]. Gencode Transcript: ENST00000393356.7 Gencode Gene: ENSG00000113300.13 Transcript (Including UTRs) Position: hg38 chr5:180,494,433-180,578,347 Size: 83,915 Total Exon Count: 14 Strand: + Coding Region Position: hg38 chr5:180,529,277-180,574,200 Size: 44,924 Coding Exon Count: 11
ID:CNOT6_HUMAN DESCRIPTION: RecName: Full=CCR4-NOT transcription complex subunit 6; EC=3.1.-.-; AltName: Full=CCR4 carbon catabolite repression 4-like; AltName: Full=Carbon catabolite repressor protein 4 homolog; AltName: Full=Cytoplasmic deadenylase; FUNCTION: Poly(A) nuclease involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. Has 3'-5' RNase activity. The CCR4-NOT complex functions as general transcription regulation complex (By similarity). In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. COFACTOR: Magnesium. SUBUNIT: Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and CNOT8. Interacts with UNR. Interacts with ZNF335. SUBCELLULAR LOCATION: Cytoplasm (Probable). Nucleus (Probable). SIMILARITY: Belongs to the CCR4/nocturin family. SIMILARITY: Contains 4 LRR (leucine-rich) repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF03372 - Endonuclease/Exonuclease/phosphatase family
ModBase Predicted Comparative 3D Structure on Q9ULM6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
