Human Gene TULP3 (ENST00000448120.7) from GENCODE V44
Description: Homo sapiens TUB like protein 3 (TULP3), transcript variant 1, mRNA. (from RefSeq NM_003324) RefSeq Summary (NM_003324): This gene encodes a member of the tubby gene family of bipartite transcription factors. Members of this family have been identified in plants, vertebrates, and invertebrates, and they share a conserved N-terminal transcription activation region and a conserved C-terminal DNA and phosphatidylinositol-phosphate binding region. The encoded protein binds to phosphoinositides in the plasma membrane via its C-terminal region and probably functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis, for instance, induced by G-protein-coupled-receptor signaling. It plays an important role in neuronal development and function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2009]. Gencode Transcript: ENST00000448120.7 Gencode Gene: ENSG00000078246.17 Transcript (Including UTRs) Position: hg38 chr12:2,890,891-2,941,138 Size: 50,248 Total Exon Count: 11 Strand: + Coding Region Position: hg38 chr12:2,890,948-2,939,444 Size: 48,497 Coding Exon Count: 11
ID:TULP3_HUMAN DESCRIPTION: RecName: Full=Tubby-related protein 3; AltName: Full=Tubby-like protein 3; FUNCTION: Negatively regulates SHH signal transduction (By similarity). Probably functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to phosphorylated inositide lipids. INTERACTION: P20929:NEB; NbExp=2; IntAct=EBI-5357290, EBI-1049657; P12520:vpr (xeno); NbExp=2; IntAct=EBI-5357290, EBI-6164519; SUBCELLULAR LOCATION: Nucleus. Cell membrane. Cell projection, cilium (By similarity). Cytoplasm (By similarity). Secreted (By similarity). Note=Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity). Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha. TISSUE SPECIFICITY: Expressed at high levels in testis, ovaries, thyroid, and spinal chord. SIMILARITY: Belongs to the TUB family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75386
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK299990 - Homo sapiens cDNA FLJ60873 complete cds, highly similar to Tubby-related protein 3. AK024246 - Homo sapiens cDNA FLJ14184 fis, clone NT2RP2005144, highly similar to Homo sapiens tubby like protein 3 (TULP3), mRNA. AK307434 - Homo sapiens cDNA, FLJ97382. AK293285 - Homo sapiens cDNA FLJ54520 complete cds, highly similar to Homo sapiens tubby like protein 3 (TULP3), mRNA. AF045583 - Homo sapiens tubby like protein 3 (TULP3) mRNA, complete cds. BC032587 - Homo sapiens tubby like protein 3, mRNA (cDNA clone MGC:45295 IMAGE:5501868), complete cds. JD399400 - Sequence 380424 from Patent EP1572962. CU689434 - Synthetic construct Homo sapiens gateway clone IMAGE:100019419 5' read TULP3 mRNA. JF432804 - Synthetic construct Homo sapiens clone IMAGE:100074121 tubby like protein 3 (TULP3) gene, encodes complete protein. KJ897716 - Synthetic construct Homo sapiens clone ccsbBroadEn_07110 TULP3 gene, encodes complete protein. AB464323 - Synthetic construct DNA, clone: pF1KB7747, Homo sapiens TULP3 gene for tubby like protein 3, without stop codon, in Flexi system. EU446713 - Synthetic construct Homo sapiens clone IMAGE:100069894; IMAGE:100011922; FLH257101.01L tubby like protein 3 (TULP3) gene, encodes complete protein. JD375097 - Sequence 356121 from Patent EP1572962. JD492656 - Sequence 473680 from Patent EP1572962. JD438439 - Sequence 419463 from Patent EP1572962. JD541514 - Sequence 522538 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O75386 (Reactome details) participates in the following event(s):