Human Gene KIF5C (ENST00000435030.6) from GENCODE V44
Description: Homo sapiens kinesin family member 5C (KIF5C), transcript variant 1, mRNA. (from RefSeq NM_004522) RefSeq Summary (NM_004522): The protein encoded by this gene is a kinesin heavy chain subunit involved in the transport of cargo within the central nervous system. The encoded protein, which acts as a tetramer by associating with another heavy chain and two light chains, interacts with protein kinase CK2. Mutations in this gene have been associated with complex cortical dysplasia with other brain malformations-2. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Jul 2015]. Gencode Transcript: ENST00000435030.6 Gencode Gene: ENSG00000168280.18 Transcript (Including UTRs) Position: hg38 chr2:148,875,227-149,026,759 Size: 151,533 Total Exon Count: 26 Strand: + Coding Region Position: hg38 chr2:148,875,618-149,011,676 Size: 136,059 Coding Exon Count: 25
ID:KIF5C_HUMAN DESCRIPTION: RecName: Full=Kinesin heavy chain isoform 5C; AltName: Full=Kinesin heavy chain neuron-specific 2; FUNCTION: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. SUBUNIT: Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1 and KLC3 (By similarity). Interacts with TRAK1. INTERACTION: P68400:CSNK2A1; NbExp=4; IntAct=EBI-717170, EBI-347804; P19784:CSNK2A2; NbExp=4; IntAct=EBI-717170, EBI-347451; Q8IXI2:RHOT1; NbExp=2; IntAct=EBI-717170, EBI-1396430; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (Probable). TISSUE SPECIFICITY: Highest expression in brain, prostate and testis, and moderate expression in kidney, small intestine and ovary. DOMAIN: Composed of three structural domains: a large globular N- terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles. SIMILARITY: Belongs to the kinesin-like protein family. Kinesin subfamily. SIMILARITY: Contains 1 kinesin-motor domain. SEQUENCE CAUTION: Sequence=BAA25457.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O60282
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
