Human Gene CLDN17 (ENST00000286808.5) from GENCODE V44
Description: Homo sapiens claudin 17 (CLDN17), mRNA. (from RefSeq NM_012131) RefSeq Summary (NM_012131): This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and is clustered with CLDN8 on chromosome 21q22.11. [provided by RefSeq, Jun 2010]. Gencode Transcript: ENST00000286808.5 Gencode Gene: ENSG00000156282.5 Transcript (Including UTRs) Position: hg38 chr21:30,165,565-30,166,805 Size: 1,241 Total Exon Count: 1 Strand: - Coding Region Position: hg38 chr21:30,165,943-30,166,617 Size: 675 Coding Exon Count: 1
ID:CLD17_HUMAN DESCRIPTION: RecName: Full=Claudin-17; FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). SUBCELLULAR LOCATION: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the claudin family. SEQUENCE CAUTION: Sequence=AAQ88461.1; Type=Frameshift; Positions=31;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00822 - PMP-22/EMP/MP20/Claudin family
ModBase Predicted Comparative 3D Structure on P56750
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005198 structural molecule activity GO:0005254 chloride channel activity GO:0005515 protein binding GO:0042802 identical protein binding
Biological Process: GO:0006811 ion transport GO:0006821 chloride transport GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules GO:1902476 chloride transmembrane transport
US Server
