Human Gene SHISA5 (ENST00000444115.5) from GENCODE V44
Description: Homo sapiens shisa family member 5 (SHISA5), transcript variant 3, mRNA. (from RefSeq NM_001272066) RefSeq Summary (NM_001272066): This gene encodes a member of the shisa family. The encoded protein is localized to the endoplasmic reticulum, and together with p53 induces apoptosis in a caspase-dependent manner. Alternative splicing results in multiple transcript variants. Related pseudogenes of this gene are found on chromosome X. [provided by RefSeq, Apr 2016]. Gencode Transcript: ENST00000444115.5 Gencode Gene: ENSG00000164054.17 Transcript (Including UTRs) Position: hg38 chr3:48,467,870-48,504,826 Size: 36,957 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr3:48,469,107-48,501,276 Size: 32,170 Coding Exon Count: 5
ID:SHSA5_HUMAN DESCRIPTION: RecName: Full=Protein shisa-5; AltName: Full=Putative NF-kappa-B-activating protein 120; AltName: Full=Scotin; Flags: Precursor; FUNCTION: Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus membrane. INDUCTION: Induced in a p53/TP53-dependent manner in response to cellular stress. DOMAIN: The proline-rich region is required for endoplasmic reticulum localization. SIMILARITY: Belongs to the shisa family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF13908 - Wnt and FGF inhibitory regulator
ModBase Predicted Comparative 3D Structure on Q8N114
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006915 apoptotic process GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043687 post-translational protein modification GO:0044267 cellular protein metabolic process GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
AF520698 - Homo sapiens scotin mRNA, complete cds. LF384594 - JP 2014500723-A/192097: Polycomb-Associated Non-Coding RNAs. MA620171 - JP 2018138019-A/192097: Polycomb-Associated Non-Coding RNAs. AK124652 - Homo sapiens cDNA FLJ42661 fis, clone BRAMY2017528, highly similar to Homo sapiens scotin (SCOTIN), mRNA. AK075441 - Homo sapiens cDNA PSEC0133 fis, clone PLACE1004507. AK056328 - Homo sapiens cDNA FLJ31766 fis, clone NT2RI2007879, weakly similar to HOMEOBOX PROTEIN HOX-A4. AB527510 - Synthetic construct DNA, clone: pF1KB5837, Homo sapiens SHISA5 gene for shisa homolog 5, without stop codon, in Flexi system. LF378646 - JP 2014500723-A/186149: Polycomb-Associated Non-Coding RNAs. MA614223 - JP 2018138019-A/186149: Polycomb-Associated Non-Coding RNAs. BC020279 - Homo sapiens shisa homolog 5 (Xenopus laevis), mRNA (cDNA clone IMAGE:4914863). AL117413 - Homo sapiens mRNA; cDNA DKFZp566M051 (from clone DKFZp566M051). AL832568 - Homo sapiens mRNA; cDNA DKFZp547M2218 (from clone DKFZp547M2218). AF151051 - Homo sapiens HSPC217 mRNA, complete cds. BC001463 - Homo sapiens shisa homolog 5 (Xenopus laevis), mRNA (cDNA clone MGC:880 IMAGE:3138644), complete cds. AK298842 - Homo sapiens cDNA FLJ54802 complete cds. AB097007 - Homo sapiens mRNA for putative NFkB activating protein, complete cds, clone: 120. AK027728 - Homo sapiens cDNA FLJ14822 fis, clone OVARC1000576. JD412220 - Sequence 393244 from Patent EP1572962. JD475834 - Sequence 456858 from Patent EP1572962. JD498720 - Sequence 479744 from Patent EP1572962. JD223766 - Sequence 204790 from Patent EP1572962. JD216440 - Sequence 197464 from Patent EP1572962. JD516549 - Sequence 497573 from Patent EP1572962. JD171377 - Sequence 152401 from Patent EP1572962. LF378645 - JP 2014500723-A/186148: Polycomb-Associated Non-Coding RNAs. MA614222 - JP 2018138019-A/186148: Polycomb-Associated Non-Coding RNAs. LF378644 - JP 2014500723-A/186147: Polycomb-Associated Non-Coding RNAs. MA614221 - JP 2018138019-A/186147: Polycomb-Associated Non-Coding RNAs. JD324591 - Sequence 305615 from Patent EP1572962. JD422316 - Sequence 403340 from Patent EP1572962. JD050525 - Sequence 31549 from Patent EP1572962. JD216266 - Sequence 197290 from Patent EP1572962. JD071760 - Sequence 52784 from Patent EP1572962. JD161276 - Sequence 142300 from Patent EP1572962. AK298799 - Homo sapiens cDNA FLJ50834 complete cds, highly similar to Homo sapiens scotin (SCOTIN), mRNA. JD323251 - Sequence 304275 from Patent EP1572962. JD321578 - Sequence 302602 from Patent EP1572962. JD052636 - Sequence 33660 from Patent EP1572962. JD126268 - Sequence 107292 from Patent EP1572962. JD224464 - Sequence 205488 from Patent EP1572962. AK310083 - Homo sapiens cDNA, FLJ17125. JD497482 - Sequence 478506 from Patent EP1572962. JD264192 - Sequence 245216 from Patent EP1572962. JD484381 - Sequence 465405 from Patent EP1572962. LF378643 - JP 2014500723-A/186146: Polycomb-Associated Non-Coding RNAs. MA614220 - JP 2018138019-A/186146: Polycomb-Associated Non-Coding RNAs. JD528871 - Sequence 509895 from Patent EP1572962. JD439974 - Sequence 420998 from Patent EP1572962. JD369199 - Sequence 350223 from Patent EP1572962. JD136351 - Sequence 117375 from Patent EP1572962. AK301191 - Homo sapiens cDNA FLJ58892 complete cds, highly similar to Homo sapiens scotin (SCOTIN), mRNA. JD233112 - Sequence 214136 from Patent EP1572962. JD090670 - Sequence 71694 from Patent EP1572962. JD119847 - Sequence 100871 from Patent EP1572962. JD119846 - Sequence 100870 from Patent EP1572962. LF378642 - JP 2014500723-A/186145: Polycomb-Associated Non-Coding RNAs. MA614219 - JP 2018138019-A/186145: Polycomb-Associated Non-Coding RNAs. JD208430 - Sequence 189454 from Patent EP1572962. JD152612 - Sequence 133636 from Patent EP1572962. JD127499 - Sequence 108523 from Patent EP1572962. CU674718 - Synthetic construct Homo sapiens gateway clone IMAGE:100017548 5' read SCOTIN mRNA. KJ902573 - Synthetic construct Homo sapiens clone ccsbBroadEn_11967 SHISA5 gene, encodes complete protein. LF378641 - JP 2014500723-A/186144: Polycomb-Associated Non-Coding RNAs. MA614218 - JP 2018138019-A/186144: Polycomb-Associated Non-Coding RNAs. LF378640 - JP 2014500723-A/186143: Polycomb-Associated Non-Coding RNAs. MA614217 - JP 2018138019-A/186143: Polycomb-Associated Non-Coding RNAs. DQ587189 - Homo sapiens piRNA piR-54301, complete sequence.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04115 - p53 signaling pathway
Reactome (by CSHL, EBI, and GO)
Protein Q8N114 (Reactome details) participates in the following event(s):
R-HSA-8952289 FAM20C phosphorylates FAM20C substrates R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275 Post-translational protein phosphorylation R-HSA-392499 Metabolism of proteins R-HSA-597592 Post-translational protein modification
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