Human Gene MRPL19 (ENST00000409374.5) from GENCODE V44
Description: Mitochondrion. (from UniProt P49406) RefSeq Summary (NM_014763): Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000409374.5 Gencode Gene: ENSG00000115364.14 Transcript (Including UTRs) Position: hg38 chr2:75,646,803-75,670,753 Size: 23,951 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr2:75,646,808-75,655,285 Size: 8,478 Coding Exon Count: 6
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P49406
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LF384133 - JP 2014500723-A/191636: Polycomb-Associated Non-Coding RNAs. MA619710 - JP 2018138019-A/191636: Polycomb-Associated Non-Coding RNAs. AK295578 - Homo sapiens cDNA FLJ57115 complete cds, highly similar to 39S ribosomal protein L19, mitochondrial precursor. AK291250 - Homo sapiens cDNA FLJ76832 complete cds, highly similar to Homo sapiens mitochondrial ribosomal protein L19 (MRPL19), mRNA. BC030144 - Homo sapiens mitochondrial ribosomal protein L19, mRNA (cDNA clone MGC:20675 IMAGE:4763405), complete cds. CU688824 - Synthetic construct Homo sapiens gateway clone IMAGE:100021909 5' read MRPL19 mRNA. KJ898095 - Synthetic construct Homo sapiens clone ccsbBroadEn_07489 MRPL19 gene, encodes complete protein. AB463123 - Synthetic construct DNA, clone: pF1KA0104, Homo sapiens MRPL19 gene for mitochondrial ribosomal protein L19, without stop codon, in Flexi system. BC021051 - Homo sapiens cDNA clone IMAGE:2967808, containing frame-shift errors. D14660 - Homo sapiens KIAA0104 mRNA, complete cds. JD483091 - Sequence 464115 from Patent EP1572962. DQ892303 - Synthetic construct clone IMAGE:100004933; FLH185045.01X; RZPDo839E08146D mitochondrial ribosomal protein L19 (MRPL19) gene, encodes complete protein; nuclear gene for mitochondrial product. DQ895502 - Synthetic construct Homo sapiens clone IMAGE:100009962; FLH185041.01L; RZPDo839E08145D mitochondrial ribosomal protein L19 (MRPL19) gene, encodes complete protein; nuclear gene for mitochondrial product. LF363136 - JP 2014500723-A/170639: Polycomb-Associated Non-Coding RNAs. MA598713 - JP 2018138019-A/170639: Polycomb-Associated Non-Coding RNAs. LF363135 - JP 2014500723-A/170638: Polycomb-Associated Non-Coding RNAs. MA598712 - JP 2018138019-A/170638: Polycomb-Associated Non-Coding RNAs. LF363133 - JP 2014500723-A/170636: Polycomb-Associated Non-Coding RNAs. MA598710 - JP 2018138019-A/170636: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P49406 (Reactome details) participates in the following event(s):
R-HSA-5389839 39S subunit binds 28S subunit:mRNA:fMet-tRNA R-HSA-5419273 Hydrolysis of GTP and dissociation of 28S and 39S subunits R-HSA-5389848 TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA R-HSA-5389857 Peptide transfer from P-site to A-site (peptide bond formation) R-HSA-5389842 TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome R-HSA-5419261 55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP R-HSA-5419281 MRRF binds 55S ribosome:mRNA:tRNA R-HSA-5419279 Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) R-HSA-5419264 MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA R-HSA-5419277 GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA R-HSA-5368286 Mitochondrial translation initiation R-HSA-5419276 Mitochondrial translation termination R-HSA-5368287 Mitochondrial translation R-HSA-5389840 Mitochondrial translation elongation R-HSA-72766 Translation R-HSA-392499 Metabolism of proteins
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