ID:TA2R7_MOUSE DESCRIPTION: RecName: Full=Taste receptor type 2 member 7; Short=T2R7; AltName: Full=STC7-4; AltName: Full=T2R30; AltName: Full=T2R6; AltName: Full=mT2R42; FUNCTION: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin- positive cells. Expressed in 15% taste bud cells in circumvallate and foliate papillae but only in 2% in fungiform papillae. Expressed in gastric and duodenal tissues. MISCELLANEOUS: Several bitter taste receptors are expressed in a single taste receptor cell. SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF05296 - Taste receptor protein (TAS2R)
ModBase Predicted Comparative 3D Structure on P59530
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0050896 response to stimulus GO:0050909 sensory perception of taste
Cellular Component: GO:0016020 membrane GO:0016021 integral component of membrane
Descriptions from all associated GenBank mRNAs
BC119329 - Mus musculus taste receptor, type 2, member 130, mRNA (cDNA clone MGC:155645 IMAGE:8734078), complete cds.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P59530 (Reactome details) participates in the following event(s):
R-MMU-3296233 T2Rs bind bitter-tasting compounds R-MMU-749454 The Ligand:GPCR:Gi complex dissociates R-MMU-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi R-MMU-380073 Liganded Gi-activating GPCR acts as a GEF for Gi R-MMU-420499 Class C/3 (Metabotropic glutamate/pheromone receptors) R-MMU-418594 G alpha (i) signalling events R-MMU-500792 GPCR ligand binding R-MMU-388396 GPCR downstream signalling R-MMU-372790 Signaling by GPCR R-MMU-162582 Signal Transduction
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Sequence and Links to Tools and Databases 
