Gene interactions and pathways from curated databases and text-mining
FEBS Lett 2000, PMID: 10664457

14-3-3tau associates with a translational control factor FKBP12-rapamycin-associated protein in T-cells after stimulation by pervanadate.

Mori, H; Inoue, M; Yano, M; Wakabayashi, H; Kido, H

Proteins of the 14-3-3 family can associate with and/or modulate the activities of a variety of proteins, such as protooncogene and oncogene products, Cdc25 phosphatases and phosphatidylinositol 3-kinase, and thus are implicated in regulation of signaling pathways and the cell cycle. We report here that treatment of Jurkat T-cells with an inhibitor of protein tyrosine phosphatase, pervanadate, induces the association of 14-3-3tau with a translational control factor, FKBP12-rapamycin-associated protein (FRAP), with significant latter's autophosphorylation. Coimmunoprecipitation of various mutants of FRAP coexpressed with 14-3-3tau in COS-7 cells revealed that 14-3-3tau binds to the C-terminal side of FRAP at unknown site(s) different from the predicted binding motifs to date.

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Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • IRef Bind Interaction: YWHAQ — MTOR
  • IRef Bind_translation Interaction: YWHAQ — MTOR (unspecified method)
  • IRef Hprd Interaction: YWHAQ — MTOR (in vitro)
  • IRef Hprd Interaction: YWHAQ — MTOR (in vivo)
  • IRef Innatedb Interaction: YWHAQ — MTOR (unknown, -)
  • IRef Mppi Interaction: YWHAQ — MTOR (coimmunoprecipitation)
  • IRef Mppi Interaction: YWHAQ — MTOR (far western blotting)
  • IRef Ophid Interaction: YWHAQ — MTOR (aggregation, confirmational text mining)
In total, 1 gene pairs are associated to this article in curated databases