Cell 1992,
PMID: 1330326
Thanos, D; Maniatis, T
In this paper, we show that both NF-kappa B and the high mobility group protein I(Y) (HMG I(Y)) are required for virus induction of the human interferon-beta (IFN-beta) gene. NF-kappa B binds to the terminal regions of a 10 bp regulatory sequence through contacts in the major groove. while HMG I(Y) recognizes the central region of the same sequence through contacts in the minor groove. Mutations that interfere with binding of either protein decrease the level of virus induction, and activation of the gene can be blocked by either NF-kappa B or HMG I(Y) antisense RNA. HMG I(Y) stimulates the binding of NF-kappa B to the IFN-beta promoter, and it may also function as a promoter-specific accessory factor for NF-kappa B transcriptional activity.
Diseases/Pathways annotated by Medline MESH: Tumor Virus Infections
Document information provided by NCBI PubMed
Text Mining Data
IFN-beta → HMG I(Y): "
The high mobility group protein
HMG I(Y) is
required for NF-kappa B-dependent virus induction of the human
IFN-beta gene
"
interferon-beta (IFN-beta) → high mobility group protein I: "
In this paper, we show that both NF-kappa B and the high mobility group protein I ( Y ) ( HMG I(Y) ) are required for virus induction of the human interferon-beta (IFN-beta) gene
"
interferon-beta (IFN-beta) → NF-kappa B: "
In this paper, we show that both NF-kappa B and the high mobility group protein I ( Y ) ( HMG I(Y) ) are required for virus induction of the human interferon-beta (IFN-beta) gene
"
Manually curated Databases
No curated data.