Gene interactions and pathways from curated databases and text-mining
Nat Cell Biol 2004, PMID: 15467718

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.

Jacinto, Estela; Loewith, Robbie; Schmidt, Anja; Lin, Shuo; Rüegg, Markus A; Hall, Alan; Hall, Michael N

The target of rapamycin (TOR) is a highly conserved protein kinase and a central controller of cell growth. In budding yeast, TOR is found in structurally and functionally distinct protein complexes: TORC1 and TORC2. A mammalian counterpart of TORC1 (mTORC1) has been described, but it is not known whether TORC2 is conserved in mammals. Here, we report that a mammalian counterpart of TORC2 (mTORC2) also exists. mTORC2 contains mTOR, mLST8 and mAVO3, but not raptor. Like yeast TORC2, mTORC2 is rapamycin insensitive and seems to function upstream of Rho GTPases to regulate the actin cytoskeleton. mTORC2 is not upstream of the mTORC1 effector S6K. Thus, two distinct TOR complexes constitute a primordial signalling network conserved in eukaryotic evolution to control the fundamental process of cell growth.

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Text Mining Data

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Manually curated Databases

  • IRef Bind Interaction: RICTOR — MTOR
  • IRef Bind Interaction: MTOR — MTOR
  • IRef Bind Interaction: Complex of MTOR-MLST8-RICTOR
  • IRef Bind Interaction: FKBP1A — MTOR
  • IRef Bind Interaction: RHOA — RTKN
  • IRef Bind Interaction: Complex of RPTOR-MLST8-MTOR
  • IRef Bind_translation Interaction: RICTOR — MTOR (experimental interaction detection)
  • IRef Bind_translation Interaction: MTOR — MTOR (experimental interaction detection)
  • IRef Bind_translation Interaction: FKBP1A — MTOR (coimmunoprecipitation)
  • IRef Bind_translation Interaction: RHOA — RTKN (affinity chromatography technology)
  • IRef Biogrid Interaction: RICTOR — MTOR (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: RPTOR — FKBP1A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: FKBP1A — MTOR (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: RPTOR — MTOR (physical association, affinity chromatography technology)
  • MIPS CORUM mTORC2 complex (mTOR/FRAP1, LST8, mAVO3/RICTOR): mTORC2 complex (mTOR/FRAP1, LST8, mAVO3/RICTOR) complex (MTOR-MLST8-RICTOR)
  • MIPS CORUM mTORC1 complex (mTOR/FRAP1, LST8, RAPTOR): mTORC1 complex (mTOR/FRAP1, LST8, RAPTOR) complex (MTOR-MLST8-RPTOR)
  • Gene Ontology Complexes TORC2 complex: TORC2 complex complex (PINK1-RICTOR-TTI1-RPL23A)
  • NCI Pathway Database mTOR signaling pathway: RAC1/GTP complex (RAC1) → mTORC2 complex (MTOR-MLST8-RICTOR-MAPKAP1-PRR5) (regulation of actin cytoskeleton organization, collaborate)
    Evidence: mutant phenotype
  • NCI Pathway Database mTOR signaling pathway: RAC1/GTP complex (RAC1) → Paxillin (PXN) (regulation of actin cytoskeleton organization, collaborate)
    Evidence: mutant phenotype
  • NCI Pathway Database mTOR signaling pathway: RAC1/GTP complex (RAC1) → RHOA/GTP complex (RHOA) (regulation of actin cytoskeleton organization, collaborate)
    Evidence: mutant phenotype
  • NCI Pathway Database mTOR signaling pathway: mTORC2 complex (MTOR-MLST8-RICTOR-MAPKAP1-PRR5) → Paxillin (PXN) (regulation of actin cytoskeleton organization, activates)
    Evidence: mutant phenotype
  • NCI Pathway Database mTOR signaling pathway: mTORC2 complex (MTOR-MLST8-RICTOR-MAPKAP1-PRR5) → RHOA/GTP complex (RHOA) (regulation of actin cytoskeleton organization, activates)
    Evidence: mutant phenotype
  • NCI Pathway Database mTOR signaling pathway: Paxillin (PXN) → RHOA/GTP complex (RHOA) (regulation of actin cytoskeleton organization, collaborate)
    Evidence: mutant phenotype
In total, 40 gene pairs are associated to this article in curated databases