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mTOR → Akt: " However, the mechanism by which Akt activates mTOR is not fully understood "
mTOR → Akt: " The known pathway by which Akt activates mTOR is via direct phosphorylation and inhibition of tuberous sclerosis complex 2 (TSC2), which is a negative regulator of mTOR "
TSC2 ⊣ Akt: " Here we establish an additional pathway by which Akt inhibits TSC2 and activates mTOR "
mTOR → Akt: " Here we establish an additional pathway by which Akt inhibits TSC2 and activates mTOR "
TSC2 ⊣ Akt: " Currently, the Akt mediated phosphorylation of TSC2 and the inhibition of AMPK mediated phosphorylation of TSC2 are viewed as two separate pathways, which activate mTOR "
TSC2 → AMPK: " Currently, the Akt mediated phosphorylation of TSC2 and the inhibition of AMPK mediated phosphorylation of TSC2 are viewed as two separate pathways, which activate mTOR "
TSC2 ⊣ Akt: " Our results demonstrate that Akt lies upstream of these two pathways and induces full inhibition of TSC2 and activation of mTOR both through direct phosphorylation and by inhibition of AMPK mediated phosphorylation of TSC2 "
TSC2 → mTOR: " Our results demonstrate that Akt lies upstream of these two pathways and induces full inhibition of TSC2 and activation of mTOR both through direct phosphorylation and by inhibition of AMPK mediated phosphorylation of TSC2 "
TSC2 → AMPK: " Our results demonstrate that Akt lies upstream of these two pathways and induces full inhibition of TSC2 and activation of mTOR both through direct phosphorylation and by inhibition of AMPK mediated phosphorylation of TSC2 "
Akt → mTOR: " Our results demonstrate that Akt lies upstream of these two pathways and induces full inhibition of TSC2 and activation of mTOR both through direct phosphorylation and by inhibition of AMPK mediated phosphorylation of TSC2 "
mTOR → Akt: " We propose that the activation of mTOR by Akt mediated cellular energy and inhibition of AMPK is the predominant pathway by which Akt activates mTOR in vivo "