Gene interactions and pathways from curated databases and text-mining
FEBS Lett 2005, PMID: 16098514

Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1.

Tee, Andrew R; Blenis, John; Proud, Christopher G

The small G protein Rheb (Ras homologue enriched in brain) is known to promote mammalian target of rapamycin (mTOR) signaling. In this study, we show that Rheb like-1 protein (RhebL1) rescues mTOR signaling during nutrient withdrawal and that tuberous sclerosis complex-1 (TSC) and TSC2 impairs RhebL1-mediated signaling through mTOR. We identify critical residues within the switch I region (N41) and 'constitutive' effector (Ec) region (Y/F54 and L56) of Rheb and RhebL1, which are required for their efficient activation of mTOR signaling. Mutation of Rheb and RhebL1 at N41 impaired their interaction with mTOR, which identifies mTOR as a common downstream target of both Rheb and RhebL1.

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Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • IRef Hprd Interaction: RHEBL1 — MTOR (in vivo)
  • IRef Hprd Interaction: RHEB — MTOR (in vivo)
  • IRef Hprd Interaction: RHEB — MTOR (in vitro)
  • IRef Hprd Interaction: EIF4EBP1 — RHEBL1 (in vivo)
  • IRef Hprd Interaction: AKT1 — RHEBL1 (in vivo)
  • IRef Intact Interaction: RHEBL1 — MTOR (physical association, anti tag coimmunoprecipitation)
  • IRef Intact Interaction: RHEB — MTOR (physical association, anti tag coimmunoprecipitation)
In total, 4 gene pairs are associated to this article in curated databases