Gene interactions and pathways from curated databases and text-mining
Mol Pharmacol 2006, PMID: 16527906

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) reduces vascular endothelial growth factor expression in allergen-induced airway inflammation.

Lee, Kyung Sun; Kim, So Ri; Park, Seoung Ju; Lee, Ho Kyung; Park, Hee Sun; Min, Kyung Hoon; Jin, Sun Mi; Lee, Yong Chul

Vascular endothelial growth factor (VEGF) plays a pivotal role in the pathogenesis of bronchial asthma. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) has been implicated in regulating cell survival signaling through the phosphoinositide 3-kinase (PI3K)/Akt pathway. The key role of PI3K in VEGF-mediated signal transduction is established. However, the effects of PTEN on VEGF-mediated signaling in asthma are unknown. This study aimed to determine the effect of PI3K inhibitors and PTEN on VEGF expression in allergen-induced airway inflammation. We have used a female C57BL/6 mouse model for asthma to determine the role of PTEN in allergen-induced airway inflammation, specifically in the expression of VEGF. Allergen-induced airway inflammation leads to increased activity of PI3K in lung tissue. These mice develop the following typical pathophysiological features of asthma in the lungs: increased numbers of inflammatory cells of the airways; airway hyper-responsiveness; increased expression of interleukin (IL)-4, IL-5, IL-13, intercellular adhesion molecule 1, vascular cell adhesion molecule 1, regulated on activation normal T cell expressed and secreted (RANTES), and eotaxin; increased vascular permeability; and increased levels of VEGF. Administration of PI3K inhibitors or adenoviruses carrying PTEN cDNA reduced the symptoms of asthma and decreased the increased levels of plasma extravasation and VEGF in allergen-induced asthmatic lungs. These results indicate that PTEN reduces VEGF expression in allergen-induced airway inflammation.

Diseases/Pathways annotated by Medline MESH: Asthma, Chromosome Deletion, Respiratory Hypersensitivity
Document information provided by NCBI PubMed

Text Mining Data

vascular endothelial growth factor ⊣ Phosphatase and tensin homolog: " Phosphatase and tensin homolog deleted on chromosome 10 ( PTEN ) reduces vascular endothelial growth factor expression in allergen induced airway inflammation "

VEGF — PI3K: " This study aimed to determine the effect of PI3K inhibitors and PTEN on VEGF expression in allergen induced airway inflammation "

VEGF — PTEN: " This study aimed to determine the effect of PI3K inhibitors and PTEN on VEGF expression in allergen induced airway inflammation "

VEGF ⊣ PTEN: " These results indicate that PTEN reduces VEGF expression in allergen induced airway inflammation "

Manually curated Databases

No curated data.