Gene interactions and pathways from curated databases and text-mining
Science 2007, PMID: 17991864

Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.

Bai, Xiaochun; Ma, Dongzhu; Liu, Anling; Shen, Xiaoyun; Wang, Qiming J; Liu, Yongjian; Jiang, Yu

The mammalian target of rapamycin, mTOR, is a central regulator of cell growth. Its activity is regulated by Rheb, a Ras-like small guanosine triphosphatase (GTPase), in response to growth factor stimulation and nutrient availability. We show that Rheb regulates mTOR through FKBP38, a member of the FK506-binding protein (FKBP) family that is structurally related to FKBP12. FKBP38 binds to mTOR and inhibits its activity in a manner similar to that of the FKBP12-rapamycin complex. Rheb interacts directly with FKBP38 and prevents its association with mTOR in a guanosine 5'-triphosphate (GTP)-dependent manner. Our findings suggest that FKBP38 is an endogenous inhibitor of mTOR, whose inhibitory activity is antagonized by Rheb in response to growth factor stimulation and nutrient availability.

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Text Mining Data

FKBP38 → Rheb: " Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38 "

mTOR → Rheb: " Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38 "

mTOR → Rheb: " We show that Rheb regulates mTOR through FKBP38, a member of the FK506 binding protein ( FKBP ) family that is structurally related to FKBP12 "

mTOR ⊣ Rheb: " Rheb interacts directly with FKBP38 and prevents its association with mTOR in a guanosine 5'-triphosphate ( GTP ) -dependent manner "

Manually curated Databases

  • IRef Innatedb Interaction: MLST8 — FKBP8 (unknown, -)
  • IRef Innatedb Interaction: EIF4EBP1 — MTOR (unknown, -)
  • IRef Innatedb Interaction: FKBP8 — MTOR (unknown, -)
In total, 3 gene pairs are associated to this article in curated databases