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HMG-CoA reductase ⊣ IL-1beta: " HMG-CoA reductase inhibition induces IL-1beta release through Rac1/PI3K/PKB dependent caspase-1 activation "
caspase-1 → Rac1/PI3K/PKB: " HMG-CoA reductase inhibition induces IL-1beta release through Rac1/PI3K/PKB dependent caspase-1 activation "
caspase-1 → IL-1beta: " HMG-CoA reductase inhibition induces IL-1beta release through Rac1/PI3K/PKB dependent caspase-1 activation "
caspase-1 → Rac1/PI3K/PKB: " HMG-CoA reductase inhibition induces IL-1beta release through Rac1/PI3K/PKB dependent caspase-1 activation "
caspase-1 → Rac1/PI3K/PKB: " HMG-CoA reductase inhibition induces IL-1beta release through Rac1/PI3K/PKB dependent caspase-1 activation "
IL-1beta ⊣ HMG-CoA reductase: " Here we show that inhibition of HMG-CoA reductase by simvastatin treatment, mimicking MKD, results in increased IL-1beta secretion in a Rac1/PI3K dependent manner "
IL-1beta — Rac1/PI3K: " Here we show that inhibition of HMG-CoA reductase by simvastatin treatment, mimicking MKD, results in increased IL-1beta secretion in a Rac1/PI3K dependent manner "
IL-1beta — Rac1/PI3K: " Here we show that inhibition of HMG-CoA reductase by simvastatin treatment, mimicking MKD, results in increased IL-1beta secretion in a Rac1/PI3K dependent manner "
IL-1beta → PKB: " Simvastatin treatment was found to activate protein kinase B (PKB)/c-akt, a primary effector of PI3K, and ectopic expression of constitutively active PKB was sufficient to induce IL-1beta release "
PKB → Rac1: " The small GTPase Rac1 was activated by simvastatin, and this was required for both PKB activation and IL-1beta secretion "
IL-1beta → Rac1: " The small GTPase Rac1 was activated by simvastatin, and this was required for both PKB activation and IL-1beta secretion "
IL-1beta → caspase-1: " IL-1beta release is mediated by caspase-1 , and simvastatin treatment resulted in increased caspase-1 activity in a Rac1/PI3K dependent manner "
caspase-1 — Rac1/PI3K: " IL-1beta release is mediated by caspase-1, and simvastatin treatment resulted in increased caspase-1 activity in a Rac1/PI3K dependent manner "
caspase-1 — Rac1/PI3K: " IL-1beta release is mediated by caspase-1, and simvastatin treatment resulted in increased caspase-1 activity in a Rac1/PI3K dependent manner "
IL-1beta ⊣ Rac1: " Importantly, inhibition of Rac1 in peripheral blood mononuclear cells isolated from MKD patients resulted in a dramatic reduction in IL-1beta release "