FEBS Lett 2009,
PMID: 19222999
Uhlenbrock, Katharina; Weiwad, Matthias; Wetzker, Reinhard; Fischer, Gunter; Wittinghofer, Alfred; Rubio, Ignacio
The small G-protein Rheb regulates cell growth via the mTORC1 complex by incompletely understood mechanisms. Recent studies document that Rheb activates mTORC1 via direct, GTP-dependent interaction with the peptidyl-prolyl-cis/trans-isomerase FKBP38, which is proposed to act as an inhibitor of mTORC1. We have conducted a comprehensive biochemical characterization of the Rheb/FKBP38 interaction. Using three different in vitro assays we did not detect an interaction between Rheb and FKBP38. Cell biological experiments illustrate that FKBP38 plays only a very minor, if any, role in mTORC1 activation. Our data document that FKBP38 is not the long-sought Rheb effector linking Rheb to mTORC1 activation.
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Text Mining Data
mTORC1 → Rheb: "
Recent studies document that
Rheb activates
mTORC1 via direct, GTP dependent interaction with the peptidyl-prolyl-cis/trans-isomerase FKBP38, which is proposed to act as an inhibitor of mTORC1
"
mTORC1 — FKBP38: "
Cell biological experiments illustrate that FKBP38 plays only a very minor, if any, role in mTORC1 activation
"
Manually curated Databases
-
IRef Intact Interaction:
RALA
—
HRAS
(direct interaction, pull down)
-
IRef Intact Interaction:
RAF1
—
HRAS
(direct interaction, pull down)
-
IRef Intact Interaction:
RAF1
—
RHEB
(direct interaction, pull down)
In total, 3 gene pairs are associated to this article in curated databases