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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining
FEBS Lett 2009, PMID: 19222999

Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway.

Uhlenbrock, Katharina; Weiwad, Matthias; Wetzker, Reinhard; Fischer, Gunter; Wittinghofer, Alfred; Rubio, Ignacio

The small G-protein Rheb regulates cell growth via the mTORC1 complex by incompletely understood mechanisms. Recent studies document that Rheb activates mTORC1 via direct, GTP-dependent interaction with the peptidyl-prolyl-cis/trans-isomerase FKBP38, which is proposed to act as an inhibitor of mTORC1. We have conducted a comprehensive biochemical characterization of the Rheb/FKBP38 interaction. Using three different in vitro assays we did not detect an interaction between Rheb and FKBP38. Cell biological experiments illustrate that FKBP38 plays only a very minor, if any, role in mTORC1 activation. Our data document that FKBP38 is not the long-sought Rheb effector linking Rheb to mTORC1 activation.

Document information provided by NCBI PubMed

Text Mining Data

mTORC1 → Rheb: " Recent studies document that Rheb activates mTORC1 via direct, GTP dependent interaction with the peptidyl-prolyl-cis/trans-isomerase FKBP38, which is proposed to act as an inhibitor of mTORC1 "

mTORC1 — FKBP38: " Cell biological experiments illustrate that FKBP38 plays only a very minor, if any, role in mTORC1 activation "

Manually curated Databases

  • IRef Intact Interaction: RALA — HRAS (direct interaction, pull down)
  • IRef Intact Interaction: RAF1 — HRAS (direct interaction, pull down)
  • IRef Intact Interaction: RAF1 — RHEB (direct interaction, pull down)
In total, 3 gene pairs are associated to this article in curated databases