Gene interactions and pathways from curated databases and text-mining
Carcinogenesis 2010, PMID: 20164123

Suppression of mTOR via Akt-dependent and -independent mechanisms in selenium-treated colon cancer cells: involvement of AMPKalpha1.

Lee, Yun-Kyoung; Park, Song Yi; Kim, Young-Min; Kim, Dong Chool; Lee, Won Sup; Surh, Young-Joon; Park, Ock Jin

Activation of the mammalian target of rapamycin (mTOR) pathway promotes tumorigenesis, and inhibiting the mammalian target of rapamycin complex 1 (mTORC1) has emerged as an attractive target for suppressing tumor growth. We found that selenium treatment of HT-29 colon cancer cells suppressed mTORC1 through Akt-independent and -dependent pathways. In Akt-independent mTORC1 inhibition in selenium-treated colon cancer cells, adenosine monophosphate-activated protein kinase (AMPK) alpha(1) was crucial for suppression of mTORC1 activity. In contrast, the Akt-dependent mTORC1 inhibition by selenium did not require AMPKalpha(1). The importance of the AMPKalpha(1)-mTORC1 pathway in mediating the antiproliferative action of selenium was examined in xenograft tumors, and the suppression of mTORC1 as well as Akt was concomitant with an increase in AMPKalpha(1) activity. These findings suggest that the antiproliferative effect of selenium is mediated by an Akt-independent AMPKalpha(1)/mTORC1 pathway or by the Akt/tuberous sclerosis complex 2 /mTORC1 pathway.

Diseases/Pathways annotated by Medline MESH: Colonic Neoplasms
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Text Mining Data

mTOR — Akt: " Suppression of mTOR via Akt dependent and -independent mechanisms in selenium treated colon cancer cells : involvement of AMPKalpha1 "

mTORC1 ⊣ Akt: " In contrast, the Akt dependent mTORC1 inhibition by selenium did not require AMPKalpha ( 1 ) "

Manually curated Databases

No curated data.