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Gene interactions and pathways from curated databases and text-mining
Cell Signal 2010, PMID: 20570724

The pivotal role of protein kinase C zeta (PKCzeta) in insulin- and AMP-activated protein kinase (AMPK)-mediated glucose uptake in muscle cells.

Liu, Li-Zhong; Cheung, Stanley C K; Lan, Lin-Lin; Ho, Stanley K S; Chan, Juliana C N; Tong, Peter C Y

Insulin and AMP-activated protein kinase (AMPK) signal pathways are involved in the regulation of glucose uptake. The integration of signals between these two pathways to maintain glucose homeostasis remains elusive. In this work, stimulation of insulin and berberine conferred a glucose uptake or surface glucose transporter 4 (GLUT4) translocation that was less than simple summation of their effects in insulin-sensitive muscle cells. Using specific inhibitors to key kinases of both pathways and PKCzeta small interference RNA, protein kinase C zeta (PKCzeta) was found to regulate insulin-stimulated protein kinase B (PKB) activation and inhibit AMPK activity on dorsal cell surface. In the presence of berberine, PKCzeta controlled AMPK activation and AMPK blocked PKB activity in perinuclear region. The inhibition effect of PKCzeta on AMPK activation or the arrestment of PKB activity by AMPK still existed in basal condition. These results suggest that there is antagonistic regulation between insulin and AMPK signal pathways, which is mediated by the switch roles of PKCzeta.

Document information provided by NCBI PubMed

Text Mining Data

insulin- ⊣ protein kinase C zeta (PKCzeta): " The pivotal role of protein kinase C zeta (PKCzeta) in insulin- and AMP activated protein kinase (AMPK) mediated glucose uptake in muscle cells "

protein kinase B (PKB) ⊣ AMPK: " Using specific inhibitors to key kinases of both pathways and PKCzeta small interference RNA, protein kinase C zeta (PKCzeta) was found to regulate insulin stimulated protein kinase B (PKB) activation and inhibit AMPK activity on dorsal cell surface "

AMPK ⊣ insulin: " Using specific inhibitors to key kinases of both pathways and PKCzeta small interference RNA, protein kinase C zeta (PKCzeta) was found to regulate insulin stimulated protein kinase B (PKB) activation and inhibit AMPK activity on dorsal cell surface "

AMPK ⊣ protein kinase C zeta (PKCzeta): " Using specific inhibitors to key kinases of both pathways and PKCzeta small interference RNA, protein kinase C zeta (PKCzeta) was found to regulate insulin stimulated protein kinase B (PKB) activation and inhibit AMPK activity on dorsal cell surface "

protein kinase B (PKB) → insulin: " Using specific inhibitors to key kinases of both pathways and PKCzeta small interference RNA, protein kinase C zeta (PKCzeta) was found to regulate insulin stimulated protein kinase B (PKB) activation and inhibit AMPK activity on dorsal cell surface "

PKB ⊣ AMPK: " In the presence of berberine, PKCzeta controlled AMPK activation and AMPK blocked PKB activity in perinuclear region "

Manually curated Databases

No curated data.