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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining
Diabetes 2010, PMID: 20724582

Expression of human chemerin induces insulin resistance in the skeletal muscle but does not affect weight, lipid levels, and atherosclerosis in LDL receptor knockout mice on high-fat diet.

Becker, Melanie; Rabe, Katja; Lebherz, Corinna; Zugwurst, Julia; Göke, Burkhard; Parhofer, Klaus G; Lehrke, Michael; Broedl, Uli C

OBJECTIVE

Chemerin is a recently discovered hepatoadipokine that regulates adipocyte differentiation as well as chemotaxis and activation of dendritic cells and macrophages. Chemerin was reported to modulate insulin sensitivity in adipocytes and skeletal muscle cells in vitro and to exacerbate glucose intolerance in several mouse models in vivo. In humans, chemerin was shown to be associated with multiple components of the metabolic syndrome including BMI, triglycerides, HDL cholesterol, and hypertension. This study aimed to examine the effect of chemerin on weight, glucose and lipid metabolism, as well as atherosclerosis in vivo.

METHODS

We used recombinant adeno-associated virus to express human chemerin in LDL receptor knockout mice on high-fat diet.

RESULTS

Expression of chemerin did not significantly alter weight, lipid levels, and extent of atherosclerosis. Chemerin, however, significantly increased glucose levels during the intraperitoneal glucose tolerance test without affecting endogenous insulin levels and the insulin tolerance test. Chemerin reduced insulin-stimulated Akt1 phosphorylation and activation of 5'AMP-activated protein kinase (AMPK) in the skeletal muscle, but had no effect on Akt phosphorylation and insulin-stimulated AMPK activation in the liver and gonadal adipose tissue.

CONCLUSIONS

Chemerin induces insulin resistance in the skeletal muscle in vivo. Chemerin is involved in the cross talk between liver, adipose tissue, and skeletal muscle.

Diseases/Pathways annotated by Medline MESH: Body Weight, Insulin Resistance
Document information provided by NCBI PubMed

Text Mining Data

Akt1 → insulin: " Chemerin reduced insulin stimulated Akt1 phosphorylation and activation of 5'AMP activated protein kinase (AMPK) in the skeletal muscle, but had no effect on Akt phosphorylation and insulin stimulated AMPK activation in the liver and gonadal adipose tissue "

Akt1 → 5'AMP activated protein kinase (AMPK): " Chemerin reduced insulin stimulated Akt1 phosphorylation and activation of 5'AMP activated protein kinase (AMPK) in the skeletal muscle, but had no effect on Akt phosphorylation and insulin stimulated AMPK activation in the liver and gonadal adipose tissue "

AMPK → insulin: " Chemerin reduced insulin stimulated Akt1 phosphorylation and activation of 5'AMP activated protein kinase (AMPK) in the skeletal muscle, but had no effect on Akt phosphorylation and insulin stimulated AMPK activation in the liver and gonadal adipose tissue "

Manually curated Databases

No curated data.