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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining
J Neurosci 2011, PMID: 21368030

RTP801/REDD1 regulates the timing of cortical neurogenesis and neuron migration.

Malagelada, Cristina; López-Toledano, Miguel Angel; Willett, Ryan T; Jin, Zong Hao; Shelanski, Michael L; Greene, Lloyd A

The generation, differentiation, and migration of newborn neurons are critical features of normal brain development that are subject to both extracellular and intracellular regulation. However, the means of such control are only partially understood. Here, we show that expression of RTP801/REDD1, an inhibitor of mTOR (mammalian target of rapamycin) activation, is regulated during neuronal differentiation and that RTP801 functions to influence the timing of both neurogenesis and neuron migration. RTP801 levels are high in embryonic cortical neuroprogenitors, diminished in newborn neurons, and low in mature neurons. Knockdown of RTP801 in vitro and in vivo accelerates cell cycle exit by neuroprogenitors and their differentiation into neurons. It also disrupts migration of rat newborn neurons to the cortical plate and results in the ectopic localization of mature neurons. On the other hand, RTP801 overexpression delays neuronal differentiation. These findings suggest that endogenous RTP801 plays an essential role in temporal control of cortical development and in cortical patterning.

Document information provided by NCBI PubMed

Text Mining Data

mTOR ⊣ RTP801/REDD1: " Here, we show that expression of RTP801/REDD1 , an inhibitor of mTOR ( mammalian target of rapamycin ) activation, is regulated during neuronal differentiation and that RTP801 functions to influence the timing of both neurogenesis and neuron migration "

mTOR ⊣ RTP801/REDD1: " Here, we show that expression of RTP801/REDD1 , an inhibitor of mTOR ( mammalian target of rapamycin ) activation, is regulated during neuronal differentiation and that RTP801 functions to influence the timing of both neurogenesis and neuron migration "

Manually curated Databases

No curated data.