Gene interactions and pathways from curated databases and text-mining
J Ethnopharmacol 2012, PMID: 22391142

BAFF/BAFF-R involved in antibodies production of rats with collagen-induced arthritis via PI3K-Akt-mTOR signaling and the regulation of paeoniflorin.

Li, Pei-Pei; Liu, Dan-Dan; Liu, Yun-Jie; Song, Shan-Shan; Wang, Qing-Tong; Chang, Yan; Wu, Yu-Jing; Chen, Jing-Yu; Zhao, Wen-Di; Zhang, Ling-Ling; Wei, Wei

BACKGROUND

Paeoniflorin (Pae) is extracted from the root of paeonia lactiflora which have attracted attention for anti-rheumatic and immune modulating properties.

OBJECTIVE

To investigate the role of PI3K/Akt/mTOR signaling mediated by BAFF/BAFF-R in antibodies production and the regulation of Pae on the signaling pathway in rats with collagen-induced arthritis (CIA).

METHODS

CIA rats were randomly separated into different groups and treated with Pae (25, 100mg/kg) from day 18 to day 38 after immunization. The effects of Pae on B lymphocytes of CIA rats were evaluated by the levels of BAFF, anti-CII antibody, IgA, IgG and IgM, and the expressions of BAFF-R, PI3K, p-Akt and mTOR.

RESULTS

In CIA rats, the levels of anti-CII antibody, IgA, IgG and IgM in serum enhanced, BAFF, BAFF-R, PI3K, p-Akt and mTOR were highly expressed. Pae (100mg/kg) obviously decreased arthritis score, relieved ankle and paw swelling, improved spleen histopathology in CIA rats, decreased the levels of IgA, IgM, IgG and anti-CII antibody, and significantly decreased the expressions of BAFF, BAFF-R, PI3K, p-Akt and mTOR.

CONCLUSIONS

PI3K/Akt/mTOR signaling mediated by BAFF/BAFF-R participates in antibodies production by B lymphocytes of CIA rats. Pae had therapeutic effects on rats with CIA. These effects might be relative to regulating PI3K/Akt/mTOR signal mediated by BAFF/BAFF-R, and down regulate the antibodies production further.

Diseases/Pathways annotated by Medline MESH: Arthritis, Experimental
Document information provided by NCBI PubMed

Text Mining Data

PI3K/Akt/mTOR signaling → BAFF/BAFF-R: " To investigate the role of PI3K/Akt/mTOR signaling mediated by BAFF/BAFF-R in antibodies production and the regulation of Pae on the signaling pathway in rats with collagen induced arthritis ( CIA ) "

PI3K/Akt/mTOR signaling → BAFF/BAFF-R: " To investigate the role of PI3K/Akt/mTOR signaling mediated by BAFF/BAFF-R in antibodies production and the regulation of Pae on the signaling pathway in rats with collagen induced arthritis ( CIA ) "

PI3K/Akt/mTOR → BAFF/BAFF-R: " To investigate the role of PI3K/Akt/mTOR signaling mediated by BAFF/BAFF-R in antibodies production and the regulation of Pae on the signaling pathway in rats with collagen induced arthritis ( CIA ) "

PI3K/Akt/mTOR → BAFF/BAFF-R: " To investigate the role of PI3K/Akt/mTOR signaling mediated by BAFF/BAFF-R in antibodies production and the regulation of Pae on the signaling pathway in rats with collagen induced arthritis ( CIA ) "

PI3K/Akt/mTOR → BAFF/BAFF-R: " To investigate the role of PI3K/Akt/mTOR signaling mediated by BAFF/BAFF-R in antibodies production and the regulation of Pae on the signaling pathway in rats with collagen induced arthritis ( CIA ) "

PI3K/Akt/mTOR → BAFF/BAFF-R: " To investigate the role of PI3K/Akt/mTOR signaling mediated by BAFF/BAFF-R in antibodies production and the regulation of Pae on the signaling pathway in rats with collagen induced arthritis ( CIA ) "

PI3K/Akt/mTOR signaling → BAFF/BAFF-R: " PI3K/Akt/mTOR signaling mediated by BAFF/BAFF-R participates in antibodies production by B lymphocytes of CIA rats "

PI3K/Akt/mTOR signaling → BAFF/BAFF-R: " PI3K/Akt/mTOR signaling mediated by BAFF/BAFF-R participates in antibodies production by B lymphocytes of CIA rats "

PI3K/Akt/mTOR → BAFF/BAFF-R: " PI3K/Akt/mTOR signaling mediated by BAFF/BAFF-R participates in antibodies production by B lymphocytes of CIA rats "

PI3K/Akt/mTOR → BAFF/BAFF-R: " PI3K/Akt/mTOR signaling mediated by BAFF/BAFF-R participates in antibodies production by B lymphocytes of CIA rats "

PI3K/Akt/mTOR → BAFF/BAFF-R: " PI3K/Akt/mTOR signaling mediated by BAFF/BAFF-R participates in antibodies production by B lymphocytes of CIA rats "

PI3K/Akt/mTOR → BAFF/BAFF-R: " PI3K/Akt/mTOR signaling mediated by BAFF/BAFF-R participates in antibodies production by B lymphocytes of CIA rats "

Manually curated Databases

No curated data.