Oncogene 1998,
PMID: 9872330
Venugopal, R; Jaiswal, A K
Antioxidant response element (ARE)-mediated expression and coordinated induction of genes encoding detoxifying enzymes is one mechanism of critical importance to cellular protection against oxidative stress. In the present report, we demonstrate that nuclear transcription factors Nrf2 and Nrf1 associate with Jun (c-Jun, Jun-B and Jun-D) proteins to upregulate ARE-mediated expression and coordinated induction of detoxifying enzymes in response to antioxidants and xenobiotics. Nrf-Jun association/heterodimerization and binding to the ARE required unknown cytosolic factor(s). Nrf2 containing one mutated leucine in its leucine zipper region was more efficient in upregulation of ARE-mediated gene expression, as compared to Nrf1 with two mutated leucines.
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Text Mining Data
Dashed line = No text mining data
Manually curated Databases
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IRef Biogrid Interaction:
NFE2L2
—
JUN
(physical association, affinity chromatography technology)
-
IRef Biogrid Interaction:
NFE2L2
—
JUN
(direct interaction, pull down)
-
IRef Biogrid Interaction:
FOS
—
JUN
(direct interaction, pull down)
-
IRef Biogrid Interaction:
NFE2L1
—
JUN
(direct interaction, pull down)
-
IRef Biogrid Interaction:
NFE2L1
—
JUN
(physical association, affinity chromatography technology)
-
IRef Hprd Interaction:
JUND
—
KEAP1
(in vivo)
-
IRef Hprd Interaction:
NFE2L1
—
JUND
(in vivo)
-
IRef Hprd Interaction:
NFE2L1
—
JUND
(in vitro)
-
IRef Hprd Interaction:
NFE2L1
—
JUNB
(in vitro)
-
IRef Hprd Interaction:
NFE2L1
—
JUN
(in vitro)
In total, 6 gene pairs are associated to this article in curated databases