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DOK2 — EGFR

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: DOK2 → EGFR (directlyIncreases, DOK2 Activity) Van Slyke et al., Mol Cell Biol 2005*
  Evidence: Dok-R has previously been shown to associate with the epidermal growth factor receptor (EGFR) and become tyrosine phosphorylated in response to EGF stimulation. Dok-R is constitutively associated with c-Src and upon recruitment to the EGFR Dok-R becomes tyrosine phosphorylated on tyrosine residue 402, which serves to recruit the negative regulator kinase, Csk.

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: DOK2 — EGFR (direct interaction, pull down) Jones et al., Curr Biol 1999*
• IRef Hprd Interaction: DOK2 — EGFR (in vitro) Jones et al., Curr Biol 1999*
• IRef Ophid Interaction: DOK2 — EGFR (aggregation, confirmational text mining) Jones et al., Curr Biol 1999*
• IRef Ophid Interaction: DOK2 — EGFR (aggregation, interologs mapping) Brown et al., Bioinformatics 2005