◀ Back to IL12A
IL12A — IL12RB1
Pathways - manually collected, often from reviews:
-
BioCarta il12 and stat4 dependent signaling pathway in th1 development:
IL-12/IL-12R/TYK2/JAK2 complex (IL12RB1-IL12RB2-IL12B_IL12A-TYK2-JAK2)
→
STAT4
(modification, activates)
-
BioCarta no2-dependent il-12 pathway in nk cells:
IL-12/IL-12R complex (IL12RB1-IL12RB2-IL12B_IL12A)
→
JAK2
(modification, activates)
-
BioCarta no2-dependent il-12 pathway in nk cells:
IL-12 (IL12B/IL12A)
→
IL-12R complex (IL12RB1-IL12RB2)
(modification, collaborate)
-
BioCarta no2-dependent il-12 pathway in nk cells:
IL-12 (IL12B/IL12A)
→
IL-12/IL-12R complex (IL12RB1-IL12RB2-IL12B_IL12A)
(modification, collaborate)
-
BioCarta no2-dependent il-12 pathway in nk cells:
IL-12R complex (IL12RB1-IL12RB2)
→
IL-12/IL-12R complex (IL12RB1-IL12RB2-IL12B_IL12A)
(modification, collaborate)
-
BioCarta il12 and stat4 dependent signaling pathway in th1 development:
IL-12 (IL12B/IL12A)
→
IL-12R/TYK2/JAK2 complex (IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
-
BioCarta il12 and stat4 dependent signaling pathway in th1 development:
IL-12 (IL12B/IL12A)
→
IL-12/IL-12R/TYK2/JAK2 complex (IL12RB1-IL12RB2-IL12B_IL12A-TYK2-JAK2)
(modification, collaborate)
-
BioCarta il12 and stat4 dependent signaling pathway in th1 development:
IL-12R/TYK2/JAK2 complex (IL12RB1-IL12RB2-TYK2-JAK2)
→
IL-12/IL-12R/TYK2/JAK2 complex (IL12RB1-IL12RB2-IL12B_IL12A-TYK2-JAK2)
(modification, collaborate)
-
KEGG Cytokine-cytokine receptor interaction:
IL12A/IL12B
→
Complex of IL12RB1-IL12RB2
(protein-protein, activation)
-
NCI Pathway Database IL12-mediated signaling events:
STAT4 (STAT4)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Chin et al., Nature 2002, Bacon et al., Proc Natl Acad Sci U S A 1995, Jacobson et al., J Exp Med 1995, Naeger et al., J Biol Chem 1999
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
RIP2 (RIPK2)
(modification, activates)
Chin et al., Nature 2002, Bacon et al., Proc Natl Acad Sci U S A 1995, Jacobson et al., J Exp Med 1995, Naeger et al., J Biol Chem 1999
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
Granzyme A (GZMA)
(transcription, activates)
Salcedo et al., J Immunol 1993
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
STAT3 (STAT3)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Jacobson et al., J Exp Med 1995, Zou et al., J Biol Chem 1997
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
STAT3 (dimer)-active complex (STAT3)
(modification, activates)
Jacobson et al., J Exp Med 1995, Zou et al., J Biol Chem 1997
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(transcription, activates)
Yang et al., Nat Immunol 2001
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
STAT3 (STAT3)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Kusaba et al., J Biol Chem 2005
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
mTOR (MTOR)
(modification, activates)
Kusaba et al., J Biol Chem 2005
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
LCK (LCK)
(modification, activates)
Pignata et al., Cell Immunol 1995
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
STAT1 (STAT1)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Gollob et al., Blood 1998
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IFN-gamma (IFNG)
(modification, activates)
Gollob et al., Blood 1998
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
STAT1 (dimer) complex (STAT1)
(modification, activates)
Gollob et al., Blood 1998
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
STAT6 (STAT6)
(modification, activates)
Moriggl et al., J Immunol 1998
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
MIP1B (CCL4)
(transcription, activates)
Galon et al., J Immunol 1999
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(transcription, activates)
Rodriguez-Galán et al., J Immunol 2005
Evidence: assay, other species
-
NCI Pathway Database IL27-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL27/IL27R/JAK2/TYK2 complex (IL27RA-JAK2-IL6ST-TYK2-IL27-EBI3)
(transcription, activates)
Chen et al., Nature 2000, Yoshida et al., Immunity 2001, Pflanz et al., Immunity 2002, Kamiya et al., J Immunol 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL12-mediated signaling events:
STAT4 (STAT4)
→
IL12/IL12R/TYK2/JAK2/SPHK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2-SPHK2)
(modification, collaborate)
Yoshimoto et al., J Immunol 2003
Evidence: reporter gene
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2/SPHK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2-SPHK2)
→
STAT4 (dimer) complex (STAT4)
(modification, activates)
Yoshimoto et al., J Immunol 2003
Evidence: reporter gene
-
NCI Pathway Database IL12-mediated signaling events:
IL1 beta (IL1B)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, activates)
Yamamoto et al., Biochem Biophys Res Commun 1999, Bacon et al., J Exp Med 1995, Hunter et al., J Immunol 1995, Presky et al., Proc Natl Acad Sci U S A 1996, Zou et al., J Biol Chem 1997, Gollob et al., Blood 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12 complex (IL12A-IL12B)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Yamamoto et al., Biochem Biophys Res Commun 1999, Bacon et al., J Exp Med 1995, Hunter et al., J Immunol 1995, Presky et al., Proc Natl Acad Sci U S A 1996, Zou et al., J Biol Chem 1997, Gollob et al., Blood 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12 complex (IL12A-IL12B)
→
IL12Rbeta1/TYK2 complex (IL12RB1-TYK2)
(modification, collaborate)
Yamamoto et al., Biochem Biophys Res Commun 1999, Bacon et al., J Exp Med 1995, Hunter et al., J Immunol 1995, Presky et al., Proc Natl Acad Sci U S A 1996, Zou et al., J Biol Chem 1997, Gollob et al., Blood 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL12Rbeta1/TYK2 complex (IL12RB1-TYK2)
(modification, collaborate)
Yamamoto et al., Biochem Biophys Res Commun 1999, Bacon et al., J Exp Med 1995, Hunter et al., J Immunol 1995, Presky et al., Proc Natl Acad Sci U S A 1996, Zou et al., J Biol Chem 1997, Gollob et al., Blood 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL12Rbeta2/JAK2 complex (IL12RB2-JAK2)
(modification, collaborate)
Yamamoto et al., Biochem Biophys Res Commun 1999, Bacon et al., J Exp Med 1995, Hunter et al., J Immunol 1995, Presky et al., Proc Natl Acad Sci U S A 1996, Zou et al., J Biol Chem 1997, Gollob et al., Blood 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(transcription, activates)
Takemoto et al., J Immunol 2006
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL12-mediated signaling events:
STAT3 (STAT3)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Gollob et al., J Immunol 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
p38 alpha (MAPK14)
(modification, activates)
Gollob et al., J Immunol 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL2/IL2R complex (IL2RA-IL2RB-IL2RG-IL2)
(modification, activates)
Gollob et al., J Immunol 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
SPHK2 (SPHK2)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Yoshimoto et al., J Immunol 2003
Evidence: assay, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
SPHK2 (SPHK2)
→
IL12/IL12R/TYK2/JAK2/SPHK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2-SPHK2)
(modification, collaborate)
Yoshimoto et al., J Immunol 2003
Evidence: assay, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL12/IL12R/TYK2/JAK2/SPHK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2-SPHK2)
(modification, collaborate)
Yoshimoto et al., J Immunol 2003
Evidence: assay, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
STAT5A (STAT5A)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Gollob et al., Blood 1998
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IFN-gamma (IFNG)
(modification, activates)
Gollob et al., Blood 1998
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(transcription, activates)
Schindler et al., J Immunol 2001
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(transcription, activates)
Yang et al., Nat Immunol 2001
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
STAT1 (STAT1)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Gollob et al., J Immunol 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
p38 alpha (MAPK14)
(modification, activates)
Gollob et al., J Immunol 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL2/IL2R complex (IL2RA-IL2RB-IL2RG-IL2)
(modification, activates)
Gollob et al., J Immunol 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
Calcineurin A alpha-beta B1 ()
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(transcription, inhibits)
Wittmann et al., J Leukoc Biol 2006
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4)
(transcription, activates)
Wittmann et al., J Leukoc Biol 2006
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12 complex (IL12A-IL12B)
→
IL12Rbeta1/TYK2 complex (IL12RB1-TYK2)
(modification, collaborate)
Diefenbach et al., Science 1999, Presky et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12 complex (IL12A-IL12B)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Diefenbach et al., Science 1999, Presky et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12Rbeta1/TYK2 complex (IL12RB1-TYK2)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Diefenbach et al., Science 1999, Presky et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
NOS2 (NOS2)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, activates)
Diefenbach et al., Science 1999, Presky et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL12Rbeta2/JAK2 complex (IL12RB2-JAK2)
(modification, collaborate)
Diefenbach et al., Science 1999, Presky et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
NF kappa B2 p52/RelB complex (NFKB2-RELB)
(translocation, activates)
Grohmann et al., Immunity 1998
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
HLX1 (HLX)
(modification, activates)
Becknell et al., Blood 2007
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
STAT4 (dimer) complex (STAT4)
(modification, activates)
Becknell et al., Blood 2007
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
(modification, activates)
Becknell et al., Blood 2007
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
SOCS1 (SOCS1)
→
IL12/IL12R/TYK2/JAK2/SOCS1 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2-SOCS1)
(modification, collaborate)
Endo et al., Nature 1997
Evidence: physical interaction
-
NCI Pathway Database IL12-mediated signaling events:
SOCS1 (SOCS1)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Endo et al., Nature 1997
Evidence: physical interaction
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2/SOCS1 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2-SOCS1)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Endo et al., Nature 1997
Evidence: physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Wu et al., Eur J Immunol 2000
:
Using an antibody specific for the human IL-12Rbeta2 subunit, the
effect of IFN-gamma, IFN-alpha,
IL-12 and IL-2 on the regulation of
IL-12R expression and IL-12 responsiveness of human T and NK cells was assessed
Nagayama et al., J Immunol 2000
:
IL-12 also
induced tyrosine phosphorylation of
IL-12Rbeta1 as well as recruitment of several tyrosine phosphorylated proteins to IL-12Rbeta1 in DCs and Con A blasts
Okazawa et al., Am J Gastroenterol 2002
(Crohn Disease...) :
The functional activity of IL- 12 and IL-18 was assessed by the
effect of recombinant
IL-12 and recombinant IL-18 on interferon-gamma production, the proliferative response, and the induction of IL-2R,
IL-12R , and IL-18R of LPLs
Hoeve et al., Eur J Immunol 2003
:
We have previously shown that human
IL-12Rbeta1-deficiency leads to impaired
IL-12 responsiveness and unusual susceptibility to infections due to mycobacteria and salmonellae ... Thus,
IL-12Rbeta1-deficiency may
impair both
IL-12- and IL-23 signaling, and both may contribute to the immunological phenotypes
Reddy et al., Cell Immunol 2007
:
CNTO 1275 inhibited upregulation of CLA,
IL-12R , IL-2Ralpha and CD40L expression and also
inhibited IL-12- and IL-23 induced IFN-gamma, IL-17A, tumor necrosis factor (TNF)-alpha, IL-2, and IL-10 secretion
Fahey et al., J Cell Mol Med 2007
(Multiple Sclerosis) :
We report that curcumin decreases
IL-12 induced STAT4 phosphorylation, IFN-gamma production, and
IL-12 Rbeta1 and beta2 expression
Kano et al., Nat Immunol 2008
:
Notably, the IRF1 dependent induction of
IL-12Rbeta1 was
essential for
IFN-gamma-IL-12 signaling but was dispensable for IL-23-IL-17 signaling
Naume et al., Cytokine 1993
:
IL-12 enhanced the
IL-12 receptor (R) expression and IL-4R expression in the CD56+ NK cells ... The increased IL-4R expression
induced by
IL-12 and the increased
IL-12R expression induced by IL-4 may explain the synergistic proliferative activity detected in response to IL-12 and IL-4
Presky et al., Ann N Y Acad Sci 1996
:
Mouse
IL-12 p40 subunit homodimer ( mo ( p40 ) 2 )
blocked 125I-huIL-12 binding to human
IL-12R beta 1 , but did not inhibit binding to human IL-12R beta 2
Wu et al., J Immunol 1997
:
To determine the
role of
IL-12Rbeta1 in mediating the biologic functions of
IL-12 in mice, we have generated IL-12Rbeta1-deficient ( IL-12Rbeta1 ( -/- ) ) mice by targeted mutation in ES cells
Jones et al., Infect Immun 1998
(Disease Models, Animal...) :
Neutralizing IL-4 and the administration of exogenous IL-12 upregulate
IL-12R expression in BALB/c mice, while the neutralization of IL-12 in C3H mice blocks
increased IL-12 receptor expression
Fujimiya et al., Clin Cancer Res 1997
(Brain Neoplasms...) :
Thus, the increased expression of the IL-2Rbeta is critical for the synergistic activation of gammadelta T cells by IL-12 plus IL-2 ; it is also probable that at least the low-affinity
IL-12R contributes to the activation of gammadelta T cells mediated by either IL-12 alone or
IL-12 plus IL-2
Hyodo et al., J Immunol 1999
:
These data suggested that NK cells develop and express
IL-12R and IL-18R in the absence of IL-12 or IL-18, and that both IL-18 and
IL-12 directly and independently
augment perforin mediated cytotoxic activity of NK cells