Gene interactions and pathways from curated databases and text-mining

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CLCN3 — IL4

Text-mined interactions from Literome

Han et al., Laryngoscope 2006 (Rhinitis, Allergic, Perennial) : After exposure to SB203580, CLC-3 expression induced by IL-4 was downregulated in HNECs in a concentration and time dependent manner ... These results confirmed that IL-4 can induce CLC-3 production in HNECs with AR through a p38 MAPK dependent pathway
Li et al., Am J Rhinol 2007 (Chronic Disease...) : Possible role of transforming growth factor beta and interleukin-4 in the up-regulation of CLC-2 and CLC-3 in chronic rhinosinusitis ... The aim of this study was to evaluate the expression of chloride channel protein CLC-2 and CLC-3 in CRS without nasal polyps ( CRSsNP ) and evaluate the roles of interleukin (IL)-4 and transforming growth factor ( TGF ) beta in the up-regulation of CLC-2 and CLC-3