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IL4 — ITK
Text-mined interactions from Literome
Au-Yeung et al., J Immunol 2007
:
A key
role for
Itk in both IFN gamma and
IL-4 production by NKT cells
Hirve et al., PloS one 2012
:
We found that FYF triple mutation
inhibits the TCR induced production of
IL-4 by impairing
ITK binding to PIP ( 3 ), reducing ITK membrane recruitment, inducing conformational changes at the T cell-APC contact site, and compromising phosphorylation of ITK and subsequent phosphorylation of PLC? ( 1 )