Gene interactions and pathways from curated databases and text-mining

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IL4 — ITK

Text-mined interactions from Literome

Au-Yeung et al., J Immunol 2007 : A key role for Itk in both IFN gamma and IL-4 production by NKT cells
Hirve et al., PloS one 2012 : We found that FYF triple mutation inhibits the TCR induced production of IL-4 by impairing ITK binding to PIP ( 3 ), reducing ITK membrane recruitment, inducing conformational changes at the T cell-APC contact site, and compromising phosphorylation of ITK and subsequent phosphorylation of PLC? ( 1 )