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MDM2 — TCHP
Text-mined interactions from Literome
Kubbutat et al., Cell Growth Differ 1999
:
Degradation of the p53
tumor suppressor protein has been shown to be
regulated by
Mdm2
Wunderlich et al., Oncogene 2002
:
Mdm2 , a major cellular
regulator of the p53
tumor suppressor protein , is also closely involved in cell cycle and apoptosis
Okumura et al., Jpn J Cancer Res 2002
:
Overexpression of the
oncoprotein MDM2 , an important
regulator of the p53
tumor suppressor protein , is often observed in breast cancer tissues and cell lines, particularly in those which express estrogen receptor alpha (ERalpha)
Yang et al., Cancer Cell 2005
:
The p53
tumor suppressor protein is
regulated by its interaction with
HDM2 , which serves as a ubiquitin ligase ( E3 ) to target p53 for degradation
Kubbutat et al., Mol Cell Biol 1998
:
The stability of the p53
tumor suppressor protein is
regulated by interaction with
Mdm2 , the product of a p53-inducible gene