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CASP10 — NOS2
Text-mined interactions from Literome
Pelletier et al., J Rheumatol 2001
(Osteoarthritis) :
Specific inhibition of either COX-2 or
iNOS reduced the level of chondrocyte death and
caspase 3
Chen et al., Acta Pharmacol Sin 2002
(Parkinsonian Disorders) :
Rg1 has protective effect against MPTP induced apoptosis and this effect may be attributed to enhancing Bcl-2 and Bcl-xl expression, reducing Bax and
iNOS expression, and
inhibiting activation of
caspase-3
Chen et al., Yao Xue Xue Bao 2002
(Parkinson Disease, Secondary) :
Ginsenoside Rg1 showed protective effect on MPTP induced apoptosis in the mouse nigral neurons and this effect may be attributable to reducing the expression of
iNOS and
inhibiting the activation of
caspase-3
Liang et al., Cardiovasc Res 2004
(Myocardial Ischemia...) :
Administration of L-arginine 10 min before reperfusion markedly decreased TUNEL positive staining cardiomyocytes, reduced myocardial
caspase-3 activity,
inhibited iNOS expression, and reduced myocardial nitrotyrosine content
Clements et al., Osteoarthritis Cartilage 2004
(Necrosis) :
Post-impact culturing was for 21 days in the
presence or absence of the
iNOS inhibitor, L-NAME, or the broad-spectrum
caspase inhibitor, Z-VAD FMK
Nakagawa et al., J Cell Biochem 2005
:
TNF-alpha induced decrease in the number of wild-type cells was significantly prevented by culture with caspase-3 inhibitor ( 10 ( -8 ) M ), while LPS- or Bay K 8644 induced decrease in cell number was significantly prevented by
caspase-3 inhibitor or N omega-nitro-L-arginine methylester ( NAME ) ( 10 ( -5 ) M ), an
inhibitor of
nitric oxide ( NO ) synthase
Gupta et al., J Am Soc Nephrol 2007
(Acute Kidney Injury...) :
Treatment of septic animals with APC reduced blood urea nitrogen, renal pathology, and chemokine expression and dramatically reduced the induction of inducible
nitric oxide synthase and
caspase-3 activation in the kidney
Chuang et al., Neuropharmacology 2007
(Epilepsy, Temporal Lobe...) :
In Sprague-Dawley rats, significant and temporally correlated upregulation of
NOS II ( 3-24h ), but not NOS I or II expression, enhanced cytosolic translocation of cytochrome c ( days 1 and 3 ),
augmented activated
caspase-3 in cytosol ( days 1, 3 and 7 ) and DNA fragmentation ( days 1, 3 and 7 ) was detected bilaterally in the hippocampal CA3 subfield after elicitation of sustained seizure activity by microinjection of kainic acid into the unilateral CA3 subfield
Holohan et al., J Cell Mol Med 2008
(Insulinoma) :
Adenoviral mediated expression of
iNOS ( AdiNOS ) alone was
sufficient to induce
caspase activity and apoptosis
Pieper et al., Antioxid Redox Signal 2008
:
VitC and MnTmPyP did not alter
iNOS expression or decrease NO levels but did
inhibit caspase 3 activity
Braun et al., Int J Neurosci 2009
(Disease Models, Animal...) :
Inducible
nitric oxide synthase mediates hippocampal
caspase-3 activation in pneumococcal meningitis
D'Agostino et al., Biol Psychiatry 2012
(Alzheimer Disease...) :
According with the neuroprotective profile of PEA observed during behavioral studies, experimental molecular and biochemical markers induced by Ab25-35 injection, such as lipid peroxidation, protein nytrosylation, inducible
nitric oxide synthase induction , and
caspase3 activation, were reduced by PEA treatment
Wang et al., Brain Res Bull 2012
(Hypoxia-Ischemia, Brain) :
In the meanwhile, the microbubbles attenuated the production of inducible
nitric oxide synthase , nitric oxide and tumor necrosis factor-alpha, as well as the
activation of
caspase-3 in insulted side of brain in neonatal rats
Mao et al., Cell Res 2013
(Shock, Septic) :
Depletion of
iNOS resulted in increased accumulation of dysfunctional mitochondria in response to LPS and ATP, which was responsible for the increased IL-1ß production and
caspase-1 activation
Ozkan et al., Antimicrob Agents Chemother 2013
:
Our study shows, for the first time in the literature, that
caspase mediated apoptosis,
iNOS , caspase 1, and calpain 1 are involved in the pathogenesis of colistin associated nephropathy