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NOS2 — PIK3R1
Text-mined interactions from Literome
Kristof et al., J Biol Chem 2003
(Inflammation) :
The
role of mTOR and
PI3K in the activation of human inducible
nitric oxide synthase transcription by cytokines and lipopolysaccharide (LPS) was investigated in lung epithelial adenocarcinoma ( A549 ) cells
Liu et al., Circulation 2003
(MAP Kinase Signaling System) :
In endothelial cells, aldosterone caused a phosphatidylinositol 3-kinase (PI3K) dependent increase in
nitric oxide synthase activity as well as
PI3K dependent
activation of extracellular signal regulated kinase 1/2 and p70 S6 kinase
Kim et al., J Immunol 2004
:
Like TGF-beta1, the
PI3K inhibitor LY294002
blocked iNOS expression and death in cultured microglial cells
Jia et al., J Biol Chem 2004
:
VEGF-D induced strong but more transient phosphatidylinositol 3-kinase (PI3K) mediated Akt activation and increased
PI3K dependent endothelial
nitric-oxide synthase phosphorylation and cell survival more weakly
Kao et al., Immunology 2005
:
Tyrosine kinase inhibitors ( genistein and tyrphostin AG126 ),
PI3K inhibitors ( wortmannin and LY 294002 ), and a p38 MAPK inhibitor ( SB 203580 )
attenuated LTA induced
iNOS expression and NO release in concentration dependent manners
Sun et al., Toxicol Appl Pharmacol 2006
:
Serine 1179 phosphorylation of endothelial
nitric oxide synthase caused by 2,4,6-trinitrotoluene through
PI3K/Akt signaling in endothelial cells
Pan et al., Biochem Pharmacol 2006
(Cocarcinogenesis...) :
Taken together, these results show that acacetin down
regulates inflammatory
iNOS and COX-2 gene expression in macrophages by inhibiting the activation of NF kappa B by interfering with the activation
PI3K/Akt/IKK and MAPK, suggesting that acacetin is a functionally novel agent capable of preventing inflammation associated tumorigenesis
Liu et al., Biochim Biophys Acta 2007
(MAP Kinase Signaling System) :
We propose that the inhibition of
PI(3)K by wortmannin in mouse macrophages enhances the PI-PLC downstream signals, and subsequently
increases the LPS induction of
iNOS expression independently of Akt pathway
Pan et al., J Agric Food Chem 2008
:
Taken together, these results show that pterostilbene down
regulates inflammatory
iNOS and COX-2 gene expression in macrophages by inhibiting the activation of NFkappaB by interfering with the activation of
PI3K/Akt/IKK and MAPK
Chern et al., Planta Med 2011
(Cerebral Infarction...) :
Andrographolide inhibits
PI3K/AKT dependent NOX2 and
iNOS expression protecting mice against hypoxia/ischemia induced oxidative brain injury
Wang et al., J Cell Physiol 2011
:
Taken together, these results suggested that in astrocytes, activation of NF-?B by ET ( B ) -dependent c-Src,
PI3K/Akt , and p42/p44 MAPK signalings is
necessary for ET-1 induced
iNOS gene up-regulation
Xia et al., Mol Cell Biochem 2012
(Asthma...) :
We investigated the
effects of
PI3K inhibitor wortmannin on
iNOS expression in bronchiole epithelial cells and NO, IL-4 and IFN-? levels in lung tissues of asthmatic rat model, which was prepared by 10 % OVA solution sensitization and 1 % OVA aerosol challenge ...
PI3K inhibitor wortmannin could
lead to reduced
iNOS expression and NO production, therefore inhibiting airway inflammatory responses
Tsai et al., Int Immunopharmacol 2012
:
Suppression of
PI3K expression by small interfering ( si ) RNA exhibited no
effect on LPS/IFN-? stimulated NO production or
iNOS protein expression in MES-13 cells
Zhang et al., Shock 2013
:
A specific
PI3K inhibitor, LY294002,
attenuated the inhibition of nitrite production and
iNOS expression produced by overexpressing a liver-specific Epac2 ( LEpac2 )