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NEUROD4 — WNT2
Text-mined interactions from Literome
Lyu et al., J Biol Chem 2003
(Carcinoma, Embryonal) :
To test the
role of
Wnt signaling in
neuronal differentiation , embryonal carcinoma P19 cells ( P19 EC ), which can be stimulated to differentiate into a neuron-like phenotype in response to retinoic acid ( RA ), were used
Hirabayashi et al., Development 2004
:
Here, we show that
Wnt signaling inhibits the self-renewal capacity of mouse cortical NPCs, and instructively
promotes their
neuronal differentiation
Hirabayashi et al., Neurosci Res 2005
:
For example, we have shown that
Wnt signaling
induces neuronal differentiation of NPCs in an instructive manner
Kubo et al., Development 2005
:
Importantly,
Wnt2b inhibited
neuronal differentiation independently of cell cycle progression
Yamaguchi et al., Development 2005
:
Canonical
Wnt signaling promotes the proliferation of retinal cells in zebrafish, and Notch signaling
inhibits neuronal differentiation through the activation of a neurogenic inhibitor, Hairy/Enhancer-of-split ( Hes )
Hirsch et al., Exp Cell Res 2007
:
During the expansion and neurogenic phases of embryonic neural development canonical
Wnt signaling initially
controls proliferation of neural progenitor cells, and later
neuronal differentiation
Olivera-Martinez et al., Development 2007
:
Wnt signals then act here to
repress neuronal differentiation
Munji et al., J Neurosci 2011
:
Wnt signaling
regulates neuronal differentiation of cortical intermediate progenitors
Kondo et al., Stem Cells 2011
:
Wnt signaling
promotes neuronal differentiation from mesenchymal stem cells through activation of Tlx3
Slawny et al., Mol Cell Neurosci 2011
(Wnt Signaling Pathway) :
Dynamic changes in
Wnt signaling are
required for
neuronal differentiation of mouse embryonic stem cells
Rogers et al., Br J Cancer 2012
(Cell Transformation, Neoplastic...) :
WNT/ß-catenin pathway activation in Myc immortalised cerebellar progenitor cells
inhibits neuronal differentiation and generates tumours resembling medulloblastoma
Wang et al., Dev Cell 2012
(Wnt Signaling Pathway) :
Previous studies have raised the possibility that
Wnt signaling may
regulate both neural progenitor maintenance and
neuronal differentiation within a single population
Rampazzo et al., Cell death & disease 2013
(Glioblastoma...) :
Wnt activation
promotes neuronal differentiation of Glioblastoma
Rosso et al., Frontiers in cellular neuroscience 2013
:
In the nervous system,
Wnt signaling also
regulates the formation and function of neuronal circuits by controlling
neuronal differentiation , axon outgrowth and guidance, dendrite development, synaptic function, and neuronal plasticity