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ADM — EPHB2

Text-mined interactions from Literome

Parameswaran et al., Eur J Pharmacol 1999 : In addition, only adrenomedullin mediated changes in ERK2 and P38 MAPK activities were inhibited by H89 while, adrenomedullin stimulated JNK1 was not consistently inhibited by the protein kinase-A inhibitor
Shichiri et al., Regul Pept 2003 : We investigated whether adrenomedullin acts as an autocrine/paracrine growth factor for cultured rat VSMCs and whether coexpressions of RAMP isoform and CRLR may mediate p42/p44 ERK/MAP kinase activation by adrenomedullin ... Cotransfection of RAMP2 or RAMP3 with CRLR into rat VSMCs potentiated activation of cAMP activity, but not of p42/p44 ERK/MAP kinase activity in response to adrenomedullin
Jiang et al., Biochim Biophys Acta 2004 : In contrast, ADM inhibited aldosterone induced fibroblast proliferation and ERK activity
Liu et al., Chin Med J (Engl) 2005 : Western blot analysis showed that ADM did not change the expression of t-MAPKs but increased p-SAPK/JNK and p-P38MAPK levels and decreased p-ERK level
Uzan et al., J Cell Physiol 2008 : Finally, the selective inhibitor of MAPK kinase ( MEK ), PD98059, abolished the apoptosis protective effect of ADM and prevented ADM activation of ERK1/2
Nagae et al., Kidney Int 2008 (Fibrosis...) : In NRK-49F renal fibroblasts, adrenomedullin reduced transforming growth factor-beta induced CTGF and fibronectin mRNA upregulation through the cyclic AMP/protein kinase A signaling pathway, and suppressed ERK phosphorylation and cell proliferation