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MAPK8 — XIAP
Text-mined interactions from Literome
Dai et al., Mol Cell Biol 2005
(Leukemia) :
Inhibition of NF-kappaB by pharmacological inhibitors or genetic strategies markedly potentiated apoptosis induced by HDACIs, and this was accompanied by enhanced reactive oxygen species ( ROS ) generation, downregulation of Mn-superoxide dismutase and
XIAP , and
c-Jun N-terminal kinase 1 ( JNK1 )
activation
Kaur et al., J Biol Chem 2005
(Carcinoma, Hepatocellular) :
X-linked inhibitor of apoptosis (XIAP) inhibits
c-Jun N-terminal kinase 1 ( JNK1 ) activation by transforming growth factor beta1 ( TGF-beta1 ) through ubiquitin mediated proteosomal degradation of the TGF-beta1 activated kinase 1 (TAK1)
Cipak et al., Neoplasma 2012
(Leukemia...) :
Inhibitors of JNK ( SP600125 ) and p38
MAPK ( SB203580 ) suppressed HEAMQ induced apoptosis and G2/M phase arrest, attenuated the activation of Bax, and
blocked down-regulation of Bcl-2,
XIAP and survivin in HEAMQ treated U937 cells
Fadó et al., Scientific reports 2013
(MAP Kinase Signaling System) :
The effects of
XIAP are
mediated by the
mitogen activated protein kinase ( MEK ) /extracellular signal regulated kinases ( ERKs ) pathway since blocking this pathway completely prevents the neuritogenesis mediated by XIAP downregulation