Gene interactions and pathways from curated databases and text-mining

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IL1A — IL5

Text-mined interactions from Literome

De Caterina et al., Am J Clin Nutr 2000 (Arteriosclerosis) : Consumption of the n-3 fatty acid docosahexaenoic acid ( DHA ; 22 : 6n-3 ) reduced endothelial expression of vascular cell adhesion molecule 1 ( VCAM-1 ), E-selectin, intercellular adhesion molecule 1 ( ICAM-1 ), interleukin 6 (IL-6), and IL-8 in response to IL-1 , IL-4, tumor necrosis factor, or bacterial endotoxin, with a half-maximal inhibitory concentration ( IC ( 50 ) ) of 1-25 micromol, ie, in the range of nutritionally achievable plasma concentrations
Zeyse et al., Biol Reprod 2000 : Induction of interleukin-1alpha production in murine Sertoli cells by interleukin-1
Hültner et al., J Immunol 2000 : Here we report that in primary mouse bone marrow derived mast cells activated by ionomycin or IgE/Ag, the proinflammatory mediator IL-1 ( alpha or beta ) up-regulated production of IL-3, IL-5 , IL-6, and IL-9 as well as TNF, i.e., cytokines implicated in many inflammatory processes including those associated with allergies and helminthic infections
Kovár et al., Parasitol Res 2002 : ELISA ( protein level ) and RNAse protection assay ( mRNA level ) showed that SGE enhanced interleukin (IL)-1alpha , IL-1beta, IL-1Ra, IL-6, and IL-12p40 cytokines, whereas production of IL-2, IL-5 , IL-10, and IL-13 was decreased
Van Damme et al., J Invest Dermatol 1990 : This study focuses on interferon-beta (IFN-beta), interleukin-6 (IL-6), and interleukin-8 (IL-8) production by fibroblasts and epithelial cells in response to interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha)
Elias et al., Chest 1990 (Pneumonia...) : To understand the processes regulating inflammation and fibrosis in the human lung, we characterized the effects of recombinant interleukin-1 , tumor necrosis factor, and gamma interferon on fibroblast proliferation, collagen production, interleukin-1-alpha production, interleukin-1-beta production, and interleukin-6 production
Muñoz et al., J Immunol 1990 : In addition, IL-1 induced IL-5 mRNA expression in these cells
Nagarkar et al., J Allergy Clin Immunol 2013 (Nasal Polyps...) : NP extracts significantly enhanced IL-1ß dependent IL-5 production in mast cells compared with uncinate tissue homogenates, and responses were significantly inhibited by anti-TSLP, suggesting that NPs contain biologically relevant levels of TSLP activity
Seckinger et al., J Immunol 1987 (Fever) : A urine inhibitor of interleukin 1 activity affects both interleukin 1 alpha and 1 beta but not tumor necrosis factor alpha
Grosset et al., Blood 1995 : In vitro biosynthesis of leukemia inhibitory factor/human interleukin for DA cells by human endothelial cells : differential regulation by interleukin-1 alpha and glucocorticoids
Naora et al., J Immunol 1994 : Furthermore, IL-5 , IL-6, and IL-10 genes were independently induced by IL-1 alpha , the phorbol ester PMA, and by forskolin, an activator of adenylate cyclase
Boxman et al., J Invest Dermatol 1993 : Low interleukin-1 activity was most probably not due to inhibition of interleukin-1 alpha production in squamous carcinoma cells-4/3T3 co-cultures because interleukin-1 alpha messenger RNA expression in squamous carcinoma cells-4 cells remained unchanged in the presence of 3T3 cells