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BMP4 — IL6
Text-mined interactions from Literome
Namba et al., Connect Tissue Res 2007
:
We examined the
effect of
IL-6 and sIL-6Ralpha on cell growth, alkaline phosphatase ( ALPase ) activity, and the expression of Sox-9, type II collagen, aggrecan core, link protein,
BMP-7 , and BMP receptors in human chondrocytes ... The expression of Sox-9 and aggrecan core did not change in the presence or absence of IL-6 and sIL-6Ralpha, whereas the expression of type II collagen, link protein,
BMP-7 , and BMP receptors increased in the
presence of both
IL-6 and sIL-6Ralpha ... These results suggest that
IL-6 and sIL-6Ralpha suppress the differentiation of chondrocytes and
induce the repair of arthrodial cartilage through an increase in the expression of cartilage matrix proteins,
BMP-7 , and BMP receptors in the cells
Yu et al., Nat Chem Biol 2008
:
In vitro, dorsomorphin
inhibited BMP- , hemojuvelin- and
interleukin 6-stimulated expression of the systemic iron regulator hepcidin, which suggests that BMP receptors regulate hepcidin induction by all of these stimuli
Ciuclan et al., Am J Respir Crit Care Med 2011
(Acute Disease...) :
Molecular analysis showed a dysregulated transforming growth
factor-ß/bone morphogenetic protein/Smad axis in SU5416- and/or hypoxia treated mice as well as augmented
induction of
IL-6 and Hif-1a levels