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CDKN1A — ESR1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CDKN1A — ESR1 (physical association, affinity chromatography technology) Kinyamu et al., Mol Cell Biol 2003*
• IRef Biogrid Interaction: CDKN1A — ESR1 (direct interaction, pull down) Fritah et al., Mol Cell Biol 2005*
• IRef Biogrid Interaction: CDKN1A — ESR1 (direct interaction, pull down) Maynadier et al., FASEB J 2008*
• IRef Hprd Interaction: CDKN1A — ESR1 (in vitro) Maynadier et al., FASEB J 2008*
• IRef Hprd Interaction: Complex of CDK2-CCNE1-ESR1-CDKN1A (in vivo) Maynadier et al., FASEB J 2008*
• IRef Hprd Interaction: Complex of 16 proteins (in vivo) Maynadier et al., FASEB J 2008*

Text-mined interactions from Literome

Gartel et al., Proc Natl Acad Sci U S A 2001 : We found that activation of a Myc-estrogen receptor fusion protein by 4-hydroxytamoxifen in mouse cells resulted in suppression of endogenous p21 transcription
Lazennec et al., Endocrinology 2001 (Breast Neoplasms...) : ER beta and ER alpha induced the expression of several endogenous genes such as pS2, TGF alpha, or the cyclin kinase inhibitor p21 but, in contrast to ER alpha, ER beta was unable to regulate c-myc proto-oncogene expression
Zhao et al., J Cell Biochem 2004 (Breast Neoplasms) : Elevated expression of the estrogen receptor prevents the down-regulation of p21Waf1/Cip1 in hormone dependent breast cancer cells
Maynadier et al., FASEB J 2008 (Breast Neoplasms) : We further demonstrate that the unliganded full-length ER alpha or the variant having the p21 ( WAF1 ) interaction region significantly increases p21 ( WAF1 ) expression, whereas ER alpha silencing reduces p21 ( WAF1 ) levels and silencing of p21 ( WAF1 ) is sufficient to prevent ER alpha induced growth inhibition