Gene interactions and pathways from curated databases and text-mining

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CDK1 — MAPK3

Text-mined interactions from Literome

Walter et al., Mol Biol Cell 2000 : In oocytes, the activation of Mos, MEK, and p42 MAPK is required for progesterone induced Cdc2 activation, and activated forms of any of these proteins can bring about Cdc2 activation in the absence of progesterone ... Finally, we present evidence that the negative regulation of Cdc2 by Mos/MEK/p42 MAPK contributes to the presence of an unusually long G2 phase in the first mitotic cell cycle ... The negative effect of p42 MAPK on Cdc2 activation may help ensure that the first mitotic cell cycle is long enough to allow karyogamy to be accomplished successfully
Liu et al., Di Yi Jun Yi Da Xue Xue Bao 2002 (Cardiomyopathy, Hypertrophic...) : [ Regulation of cyclin dependent kinase inhibitors by mitogen activated protein kinase in angiotensin II-stimulated vascular smooth muscle cell hypertrophy ] ... To investigate the role of mitogen activated protein kinase ( MAPK ) in the regulation of cyclin dependent kinase inhibitors ( CDKI ) in the process of vascular smooth muscle cell ( VSMC ) hypertrophy induced by angiotensin II stimulation
Miyoshi et al., Cancer Res 2004 : Conversely, BITC is likely to confine the Jurkat cells in the G(2)-M phase mainly through the p38 MAPK pathway because only the p38 MAPK inhibitor significantly attenuated the accumulation of inactive phosphorylated Cdc2 protein and the G(2)-M arrested cell numbers
Yue et al., Curr Biol 2004 : Immunodepletion of Mos from interphase egg extracts was found to abolish Delta90 cyclin B-Cdc2 stimulated p42 MAPK activation
Vogt et al., J Pharmacol Exp Ther 1998 (Cell Transformation, Viral) : Rather, SC-alphaalphadelta9 decreased insulin-like growth factor-1 receptor tyrosine phosphorylation, receptor expression, mitogen activated protein kinase activation and levels of the cyclin dependent kinase Cdc2