◀ Back to RHO

FYN — RHO

Text-mined interactions from Literome

Calautti et al., J Cell Biol 2002 : Endogenous Rho activity increases in differentiating keratinocytes and is required for both Fyn kinase activation and increased tyrosine phosphorylation of beta- and gamma-catenin, which is associated with the establishment of keratinocyte cell-cell adhesion ... Conversely, expression of constitutive active Rho is sufficient to promote cell-cell adhesion through a tyrosine kinase- and Fyn dependent mechanism, trigger Fyn kinase activation, and induce tyrosine phosphorylation of beta- and gamma-catenin and p120ctn
Wang et al., J Biol Chem 2012 : Moreover, Fyn was required to suppress Ras and Rho and for p27Kip1 accumulation, and Rho inhibition in PTPa-deficient cells restored expression of p27Kip1 ... We propose that PTPa-Fyn signaling negatively regulates OPC proliferation by down regulating Ras and Rho , leading to p27Kip1 accumulation and cell cycle exit