Tu et al., Methods Enzymol 2004
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Both PA and PIP3 can inhibit RGS4 GAP activity and their inhibition is additive, suggesting that PA and PIP3 interact with different domains of RGS4
Costa et al., Proc Natl Acad Sci U S A 2007
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Together with the finding that chemoattractants stimulate a PIP3 dependent GAP activation in wild-type macrophages, these results identify a molecular mechanism involving PI3K- and RacGAP dependent negative control of Rac that limits and fine-tunes feedback loops promoting cell polarization and directional motility
Randazzo et al., J Biol Chem 1994
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PIP2 alone stimulated ARF GAP activity up to 30-fold with a half-maximal effect at 100-300 microM but had no effect on the GTPase rate of ARF alone
Randazzo et al., Biochem J 1997
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In contrast, GAP2 was stimulated 20-40-fold by PIP2 ... PA and PS had no effect by themselves but PA increased GAP2 activity in the presence of PIP2