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AGRN — LRP4

Pathways - manually collected, often from reviews:

• Reactome Reaction: AGRN → LRP4 (reaction)
• Reactome Reaction: AGRN → LRP4 (indirect_complex)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• STRING interaction: LRP4 — AGRN (interaction, mapped from pdb)
• STRING interaction: AGRN — LRP4 (interaction, mapped from pdb)

Text-mined interactions from Literome

Kim et al., Cell 2008 : Here, we report that Lrp4 , a member of the LDLR family, is a receptor for Agrin, forms a complex with MuSK, and mediates MuSK activation by Agrin
Zhang et al., Neuron 2008 (Synaptic Transmission) : Suppression of LRP4 expression in muscle cells attenuates agrin binding, agrin induced MuSK tyrosine phosphorylation, and AChR clustering
Singhal et al., Dev Neurobiol 2011 : The roles of their many potential receptors and/or binding proteins have been more difficult to assess at the genetic level due to the complexity of membrane interactions with these large proteins, but roles for MuSK-LRP4 in agrin signaling and for integrins, dystroglycan, and voltage gated calcium channels in laminin dependent phenotypes have been identified