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APOB — PDGFC

Text-mined interactions from Literome

Fox et al., Proc Natl Acad Sci U S A 1986 : We have examined the effect of native plasma low density lipoprotein (LDL) and chemically modified LDL on production of PDGF-c by EC ... Acetyl-LDL, but not native LDL , suppressed the production of PDGF-c by bovine aortic EC ... Acetyl-LDL suppressed PDGF-c production in both bovine aortic and human umbilical vein EC, but not in rat heart EC ... Dimethylpropanediamine-LDL , a cationic modified lipoprotein, also inhibited PDGF-c production
Fox et al., J Biol Chem 1987 : LDL modified in vitro by free radical lipid peroxidation quantitatively inhibited PDGF-c production ... Chloroquine, monensin, and NH4Cl, inhibitors of lysosomal hydrolytic activity, did not prevent acetyl-LDL mediated inhibition of PDGF-c production, indicating that cellular metabolism of the lipoprotein was not required for the inhibition ... Furthermore, acetyl-LDL suppressed PDGF-c production by endothelial cells even in the presence of butylated hydroxytoluene, an inhibitor of lipid peroxidation, suggesting that cellular propagation of free radicals was not required for the inhibition