Takaya et al., Mol Biol Cell 2007
:
R-Ras regulates exocytosis by Rgl2/Rlf mediated activation of RalA on endosomes
van den Berg et al., J Biol Chem 2013
:
Following increased ROS, RALA is activated by the exchange factor RLF ( RalGDS-like factor ), which is in complex with JIP1 ( C-Jun-amino-terminal interacting protein 1 ) and JNK
Wolthuis et al., EMBO J 1997
(Cell Transformation, Neoplastic) :
Rlf exhibits guanine nucleotide exchange activity towards the small GTPase Ral and, importantly, Rlf induced Ral activation is stimulated by active Ras