Horita et al., J Exp Med 2000
(Blast Crisis...) :
Here, we show that the interleukin 3-independent expression of the antiapoptotic protein, Bcl-xL , is induced by Bcr-Abl through activation of signal transducer and activator of transcription ( Stat ) 5
Amarante-Mendes et al., Oncogene 1998
:
Interestingly, wild type and mutant Bcr - Abl induced in HL-60 cells a dramatic down regulation of Bcl-2 and increased the levels of Bcl-xL