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EPHB2 — SLC22A3
Text-mined interactions from Literome
Lan et al., Carcinogenesis 2004
:
Although
Raf/MEK/ERK signaling
causes EMT , the mechanisms, including the signaling pathways, are as yet unclear
Xie et al., Neoplasia (New York, N.Y.) 2004
(MAP Kinase Signaling System) :
However, the
role of
Erk in the induction of TGF-beta1 mediated
EMT remains unclear
Rhyu et al., J Am Soc Nephrol 2005
(Fibrosis...) :
Chemical inhibition of
ERK but not p38 MAPK inhibited TGF-beta1 induced Smad 2 phosphorylation, and both MAPK inhibitors
inhibited TGF-beta1- and H ( 2 ) O ( 2 ) -induced
EMT
Chen et al., J Biol Chem 2006
(MAP Kinase Signaling System) :
Dominant negative MEK1, MEK2, and
ERK2 block PPARgamma induced
EMT , whereas constitutively active MEK1 and MEK2 induce a mesenchymal phenotype similar to that evoked by PPARgamma
Zhang et al., J Am Soc Nephrol 2007
(Disease Models, Animal...) :
These findings support important profibrotic roles for plasmin that include PAR-1 dependent
ERK signaling and
EMT induction
Pollack et al., American journal of physiology. Renal physiology 2007
(MAP Kinase Signaling System) :
Oncostatin M-induced effects on
EMT in human proximal tubular cells : differential
role of
ERK signaling
Choi et al., Drug News Perspect 2008
(Disease Progression...) :
Recent studies indicate that the
EMT induced by TMPRSS4
involves activation of extracellular signal regulated kinase (
ERK ) 1/2 and mitogen activated protein kinase ( MAPK )
Zuo et al., Mol Biol Cell 2009
:
Activation of
ERK or p38 is
required for both TGF-beta induced
EMT and cell migration, whereas PI3K/Akt is necessary only for TGF-beta promoted cell migration but not for EMT
Ardura et al., J Am Soc Nephrol 2010
(Disease Models, Animal...) :
Moreover, inhibition of
ERK1/2 blocked
EMT induced by either PTHrP ( 1-36 ), TGF-beta1, EGF, or VEGF
Shin et al., Mol Cell 2010
:
Further,
ERK2 but not ERK1 overexpression is
sufficient to induce
EMT ... Remarkably,
ERK2 signaling to DEF motif containing targets is
required to induce
EMT and correlates with increased migration, invasion, and survival ... Importantly, the late-response gene product Fra1 is necessary for Ras- and
ERK2 induced
EMT through upregulation of ZEB1/2 proteins
Barnett et al., Biochem Biophys Res Commun 2011
(Prostatic Neoplasms) :
In conclusion, this study shows for the first time that Snail transcription factor can regulate oxidative stress enzymes and increase ROS mediated
EMT regulated in part by
ERK activation
Zhou et al., Zhongguo Fei Ai Za Zhi 2013
:
In NSCLC cells, ENO1 overexpression can
inhibit EMT in vitro by suppressing
ERK1/2 phosphorylation