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HLA-E — IFNG
Text-mined interactions from Literome
Hurks et al., Invest Ophthalmol Vis Sci 2001
(Melanoma...) :
Notably, all cell lines expressed
HLA-E , and this expression was significantly
enhanced by
interferon-gamma
Barrett et al., Mol Cell Biol 2004
:
We have now identified and characterized a cell type restricted enhancer of
IFN-gamma mediated induction of
HLA-E gene transcription, designated the upstream interferon response region ( UIRR ), which is located immediately upstream of the IRR ... The UIRR mediates a three- to eightfold enhancement of
IFN-gamma induction of
HLA-E transcription in some cell lines but not in others, and it functions only in the presence of an adjacent IRR ... Forced expression of GATA-1 in nonexpressing U937 cells resulted in a four- to fivefold enhancement of the IFN-gamma response from HLA-E promoter constructs containing a wild-type but not a GATA-1 mutant UIRR sequence and increased the
IFN-gamma response of the endogenous
HLA-E gene ... Knockdown of GATA-1 expression in K562 cells resulted in a approximately 4-fold decrease in the
IFN-gamma response of the endogenous
HLA-E gene, consistent with loss of the increase in IFN-gamma response of HLA-E promoter-driven constructs containing the UIRR in wild-type K562 cells ... We propose that the GATA-1 transcription factor represents a cell type restricted mediator of
IFN-gamma induction of the
HLA-E gene
Salerno-Gonçalves et al., J Immunol 2004
:
These results demonstrate that
HLA-E binds nonamer peptides derived from bacterial proteins and
trigger CD8+ mediated lysis and
IFN-gamma production when exposed to infected targets, raising the possibility that this novel effector mechanism might contribute to host defense against intracellular bacterial infections
Derré et al., J Immunol 2006
(Disease Susceptibility...) :
IFN-gamma significantly
increased the surface expression of
HLA-E and the shedding of soluble HLA-E by these cells, in a metalloproteinase dependent fashion
Browne et al., J Immunol 2006
:
In contrast with HLA-A,
IFN-gamma induced expression of the HLA class Ib gene,
HLA-E , was not affected by either 5'-methyl-5'-thioadenosine or leptomycin B ... These results provide proof of principle that it is possible to differentially modulate the
IFN-gamma induced expression of the
HLA-E and HLA-A genes, whose products often mediate opposing effects on cellular immunity to tumor cells, pathogens, and autoantigens
Coupel et al., Blood 2007
(Vasculitis) :
We demonstrate that tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and
interferon gamma (IFNgamma) up-regulate the cell-surface expression of HLA-E on ECs in vitro and
induce the release of soluble
HLA-E ( sHLA-E )
Levy et al., Int J Oncol 2008
(Carcinoma...) :
Moreover, we analysed HLA-E expression in several colorectal cancer cell lines and demonstrated that
IFN-gamma upregulates the expression of membrane
HLA-E in vitro
Nguyen et al., Bone Marrow Transplant 2009
(Leukemia, Myeloid, Acute) :
We show that
IFN-gamma produced by immature CD56 ( bright ) NK cells
upregulates cell surface expression of
HLA-E on AML blasts and that this upregulation protects leukemic cells from NK-mediated cell lysis through the mediation of CD94/NKG2A, an inhibitory receptor overexpressed on NK cells after haploidentical SCT
Weiss et al., Transplantation 2009
:
Further,
HLA-E/hubeta2m expression on porcine endothelial cells
inhibited the secretion of
interferon (IFN)-gamma by co-cultured human NK cells